![](/images/graphics-bg.png)
Rebamipide with Proton Pump Inhibitors (PPIs) versus PPIs Alone for the Treatment of Endoscopic Submucosal Dissection-Induced Ulcers: A Meta-analysis
المؤلفون المشاركون
Liu, Junyuan
Xiong, Zhencheng
Geng, Xuhua
Cui, Meihua
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
To contrast the effect of rebamipide with proton pump inhibitors (PPIs) versus PPIs alone for the treatment of endoscopic submucosal dissection (ESD-) induced ulcers.
Methods.
PubMed, Embase, the Cochrane library, the WanFang database, and China National Knowledge Infrastructure (CNKI) were searched to identify studies that met the inclusion criteria.
Results.
Nine randomized controlled trials (RCTs) were recognized, including 1170 patients.
In general, rebamipide plus PPIs acted better than PPIs alone against ESD-induced ulcers at four weeks (RR=1.42, 95% CI: 1.13-1.78, P=0.003) but showed no significant differences at eight weeks (RR=1.03, 95% CI: 0.97-1.10, P=0.315).
The use of rebamipide plus PPIs was superior to PPIs alone for ESD-induced ulcers greater than 20 mm in size (20-40 mm: RR=1.98, 95% CI: 1.22-3.23, P=0.006; >40 mm: RR=5.14, 95% CI: 1.49-17.74, P=0.010).
In addition, rebamipide plus PPI therapy was discovered to be significantly more effective than PPIs alone for lower ESD-induced ulcers (RR=1.82, 95% CI: 1.04-3.20, P=0.037).
There were no significant differences between the treatment groups with the ulcer reduction rate.
Conclusion.
Evidences now available show rebamipide plus PPIs is practical for protecting against ESD-induced ulcers at four weeks but not at eight weeks, especially large ulcers (>20 mm).
However, we still need more high-quality RCTs in the future to supplement our conclusions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Junyuan& Xiong, Zhencheng& Geng, Xuhua& Cui, Meihua. 2020. Rebamipide with Proton Pump Inhibitors (PPIs) versus PPIs Alone for the Treatment of Endoscopic Submucosal Dissection-Induced Ulcers: A Meta-analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1136636
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Junyuan…[et al.]. Rebamipide with Proton Pump Inhibitors (PPIs) versus PPIs Alone for the Treatment of Endoscopic Submucosal Dissection-Induced Ulcers: A Meta-analysis. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1136636
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Junyuan& Xiong, Zhencheng& Geng, Xuhua& Cui, Meihua. Rebamipide with Proton Pump Inhibitors (PPIs) versus PPIs Alone for the Treatment of Endoscopic Submucosal Dissection-Induced Ulcers: A Meta-analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1136636
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136636
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)