Serum Cytokine Profile in Relation to the Severity of Coronary Artery Disease
المؤلفون المشاركون
Ge, Yiyue
Wang, Xiangming
Xu, Di
Min, Xiaoyan
Lu, Miao
Tu, Su
Zhou, Chuanwei
Wang, Sen
Pang, Sisi
Qian, Jin
Cao, Kejiang
Guo, Yan
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objectives.
To investigate the potential association of a set of serum cytokines with the severity of coronary artery disease (CAD).
Methods.
A total of 201 patients who underwent coronary angiography for chest discomfort were enrolled.
The concentrations of serum IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-9, and IL-17 were determined by xMAP multiplex technology.
The CAD severity was assessed by Gensini score (GS).
Results.
The serum levels of TNF-α, IL-6, IL-9, IL-10, and IL-17 were significantly higher in high GS group (GS ≥ 38.5) than those in low GS group (GS < 38.5).
Positive correlations were also found between these cytokines and the severity of CAD.
After adjustment for other associated factors, three serum cytokines (IL-6, IL-9, and IL-17) and two clinical risk factors (creatinine and LDL-C) were identified as the independent predictors of increased severity of CAD.
ROC curve analysis revealed that the logistic regression risk prediction model had a good performance on predicting CAD severity.
Conclusions.
Combinatorial analysis of serum cytokines (IL-6, IL-9, and IL-17) with clinical risk factors (creatinine and LDL-C) may contribute to the evaluation of the severity of CAD and may help guide the risk stratification of angina patients, especially in primary health facilities and in the catheter lab resource-limited settings.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Min, Xiaoyan& Lu, Miao& Tu, Su& Wang, Xiangming& Zhou, Chuanwei& Wang, Sen…[et al.]. 2017. Serum Cytokine Profile in Relation to the Severity of Coronary Artery Disease. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136637
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Min, Xiaoyan…[et al.]. Serum Cytokine Profile in Relation to the Severity of Coronary Artery Disease. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1136637
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Min, Xiaoyan& Lu, Miao& Tu, Su& Wang, Xiangming& Zhou, Chuanwei& Wang, Sen…[et al.]. Serum Cytokine Profile in Relation to the Severity of Coronary Artery Disease. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136637
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136637
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر