Mitochondria Associated MicroRNA Expression Profiling of Heart Failure
المؤلفون المشاركون
Wang, Xiaoxia
Song, Chun
Zhou, Xiao
Han, Xiaorui
Li, Jun
Wang, Zengwu
Shang, Haibao
Liu, Yuli
Cao, Huiqing
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Heart failure (HF) is associated with mitochondrial dysfunction and energy metabolism impairment.
MicroRNAs are implicated in the development of heart failure.
However, the mitochondria enriched microRNA during heart failure remains elusive.
Here, we generated a pressure overload-induced early and late stage heart failure model at 4 weeks and 8 weeks following transverse aortic constriction (TAC) in mice.
We found that expression of mitochondrion protein COX4 was highly enriched in isolated mitochondria from cardiac tissues while GAPDH could hardly be detected.
Furthermore, small RNA sequencing for mitochondria RNAs from failing hearts was performed.
It was found that 69 microRNAs were upregulated and 2 were downregulated in early heart failure, while 16 microRNAs were upregulated and 6 were downregulated in late heart failure.
15 microRNA candidates were measured in both mitochondria and total cardiac tissues of heart failure by real-time PCR.
MiR-696, miR-532, miR-690, and miR-345-3p were enriched in mitochondria from the failing heart at early stage.
Bioinformatics analysis showed that mitochondria enriched microRNAs in HF were associated with energy metabolism and oxidative stress pathway.
For the first time, we demonstrated microRNAs were enriched in mitochondria during heart failure, which established a link between microRNA and mitochondrion in heart failure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xiaoxia& Song, Chun& Zhou, Xiao& Han, Xiaorui& Li, Jun& Wang, Zengwu…[et al.]. 2017. Mitochondria Associated MicroRNA Expression Profiling of Heart Failure. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136647
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Xiaoxia…[et al.]. Mitochondria Associated MicroRNA Expression Profiling of Heart Failure. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1136647
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xiaoxia& Song, Chun& Zhou, Xiao& Han, Xiaorui& Li, Jun& Wang, Zengwu…[et al.]. Mitochondria Associated MicroRNA Expression Profiling of Heart Failure. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136647
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136647
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر