![](/images/graphics-bg.png)
miRNAs: Important Targets for Oral Cancer Pain Research
المؤلفون المشاركون
Pereira, Cláudia Maria
Sehnem, Dayany
da Fonseca, Estevão Oliveira
Barboza, Heráclito Fernando Gurgel
DaSilva, Alexandre F. M.
Moura-Neto, Vivaldo
DosSantos, Marcos Fabio
Carvalho, Antonio Carlos Pires
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Pain is a symptom shared by an incredible number of diseases.
It is also one of the primary conditions that prompt individuals to seek medical treatment.
Head and neck squamous cell carcinoma (HNSCC) corresponds to a heterogeneous disease that may arise from many distinct structures of a large, highly complex, and intricate region.
HNSCC affects a great number of patients worldwide and is directly associated with chronic pain, which is especially prominent during the advanced stages of oral squamous cell carcinoma (OSCC), an anatomical and clinical subtype that corresponds to the great majority oral cancers.
Although the cellular and molecular bases of oral cancer pain have not been fully established yet, the results of recent studies suggest that different epigenetic mechanisms may contribute to this process.
For instance, there is strong scientific evidence that microRNAs (miRNAs), small RNA molecules that do not encode proteins, might act by regulating the mechanisms underlying cancer-related pain.
Among the miRNAs that could possibly interfere in pain-signaling pathways, miR-125b, miR-181, and miR-339 emerge as some of the most promising candidates.
In fact, such molecules apparently contribute to inflammatory pain.
Moreover, these molecules possibly influence the activity of endogenous pain control systems (e.g., opioidergic and serotonergic systems), which could ultimately result in peripheral and central sensitization, central nervous system (CNS) phenomena innately associated with chronic pain.
This review paper focuses on the current scientific knowledge regarding the involvement of miRNAs in cancer pain, with special attention dedicated to OSCC-related pain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pereira, Cláudia Maria& Sehnem, Dayany& da Fonseca, Estevão Oliveira& Barboza, Heráclito Fernando Gurgel& Carvalho, Antonio Carlos Pires& DaSilva, Alexandre F. M.…[et al.]. 2017. miRNAs: Important Targets for Oral Cancer Pain Research. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136655
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pereira, Cláudia Maria…[et al.]. miRNAs: Important Targets for Oral Cancer Pain Research. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1136655
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pereira, Cláudia Maria& Sehnem, Dayany& da Fonseca, Estevão Oliveira& Barboza, Heráclito Fernando Gurgel& Carvalho, Antonio Carlos Pires& DaSilva, Alexandre F. M.…[et al.]. miRNAs: Important Targets for Oral Cancer Pain Research. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136655
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136655
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)