Neutrophil-to-Lymphocyte Ratio and Albumin: New Serum Biomarkers to Predict the Prognosis of Male Alcoholic Cirrhosis Patients
المؤلفون المشاركون
Zhang, Mingyuan
Zhang, Yu
Liu, Lili
Prithweeraj, Mozumder
Xu, Hongqin
Wu, Ruihong
Wen, Xiaoyu
Niu, Junqi
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background and Aims.
Alcohol-associated liver disease is exhibiting an increasing disease burden.
In terms of pathogenesis, inflammation is closely related to alcohol-induced liver injury.
The neutrophil-to-lymphocyte ratio (NLR) is a novel inflammatory biomarker.
Here, we aim to evaluate the role of the NLR and other biomarkers in predicting short-term mortality in alcoholic cirrhotic patients.
Methods.
This was a retrospective study that included 459 male alcoholic cirrhosis patients.
Among them, 345 patients completed follow-up.
Based on their 30-day mortality information, patients were separated into surviving and nonsurviving groups.
Demographic, clinical, and biochemical features were collected for further analysis.
Logistic regression was used to identify factors associated with short-term mortality, and receiver operating characteristic (ROC) curve analysis was used to establish the predictive value of these factors.
Results.
The prognostic scores were significantly higher in the nonsurviving group than in the surviving group: NLR: 5.5 vs.
3.2 (P<0.001), model for end-stage liver disease (MELD): 15.4 vs.
7.9 (P<0.001), Maddrey’s discriminant function (MDF): 39.8 vs.
12.7 (P<0.001), and the integrated MELD (i-MELD): 37.9 vs.
28.4 (P<0.001).
Logistic regression demonstrated that albumin (ALB), NLR, and i-MELD values were significantly correlated with patient death in 30 days.
On ROC analysis, the diagnostic accuracy for 30-day mortality of the NLR (area under the ROC curve (AUROC) of 0.72, P<0.001) was similar to that of the MELD or i-MELD (AUROCs of 0.71 and 0.74, respectively, P<0.001).
The new biomarker, NLA, calculated as 100×NLR/ALB, had the best prognostic value.
The cutoff values of the NLR and NLA for predicting 30-day mortality were 4.2 and 19.6, respectively.
Conclusions.
The NLR and its related biomarker NLA are simple and robust predictors of 30-day mortality in alcoholic cirrhosis patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Mingyuan& Zhang, Yu& Liu, Lili& Prithweeraj, Mozumder& Xu, Hongqin& Wu, Ruihong…[et al.]. 2020. Neutrophil-to-Lymphocyte Ratio and Albumin: New Serum Biomarkers to Predict the Prognosis of Male Alcoholic Cirrhosis Patients. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1136709
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Mingyuan…[et al.]. Neutrophil-to-Lymphocyte Ratio and Albumin: New Serum Biomarkers to Predict the Prognosis of Male Alcoholic Cirrhosis Patients. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1136709
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Mingyuan& Zhang, Yu& Liu, Lili& Prithweeraj, Mozumder& Xu, Hongqin& Wu, Ruihong…[et al.]. Neutrophil-to-Lymphocyte Ratio and Albumin: New Serum Biomarkers to Predict the Prognosis of Male Alcoholic Cirrhosis Patients. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1136709
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136709
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر