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Preservation of Myocardial Perfusion and Function by Keeping Hypertrophied Heart Empty and Beating for Valve Surgery: An In Vivo MR Study of Pig Hearts
المؤلفون المشاركون
Wang, Jian
Deng, Jixian
Freed, Darren H.
Tian, Ganghong
Xiang, Bo
Lin, Hung-Yu
Arora, Rakesh C.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objectives.
Normothermic hyperkalemic cardioplegia arrest (NHCA) may not effectively preserve hypertrophied myocardium during open-heart surgery.
Normothermic normokalemic beating perfusion (NNBP), keeping hearts empty-beating, was utilized as an alternative to evaluate its cardioprotective role.
Materials and Methods.
Twelve hypertrophied pig hearts at 58.6 ± 7.2 days after ascending aorta banding underwent NNBP and NHCA, respectively.
Near infrared myocardial perfusion imaging with indocyanine green (ICG) was conducted to assess myocardial perfusion.
Left ventricular (LV) contractile function was assessed by cine MRI.
TUNEL staining and western blotting for caspase-3 cleavage and cardiac troponin I (cTnI) degradation were conducted in LV tissue samples.
Results.
Ascending aortic diameter was reduced by 52.7%±0.4% at approximately fifty-eight days after banding.
LV wall thickness was significantly higher in aorta banding than in sham operation.
Myocardial blood flow reflected by maximum ICG absorbance value was markedly higher in NNBP than in NHCA.
The amount of apoptotic cardiomyocyte was significantly lower in NNBP than in NHCA.
NNBP alleviated caspase-3 cleavage and cTnI degradation associated with NHCA.
NNBP displayed a substantially increased postoperative ejection fraction relative to NHCA.
Conclusions.
NNBP was better than NHCA in enhancing myocardial perfusion, inhibiting cardiomyocyte apoptosis, and preserving LV contractile function for hypertrophied hearts.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Jian& Xiang, Bo& Deng, Jixian& Lin, Hung-Yu& Freed, Darren H.& Arora, Rakesh C.…[et al.]. 2017. Preservation of Myocardial Perfusion and Function by Keeping Hypertrophied Heart Empty and Beating for Valve Surgery: An In Vivo MR Study of Pig Hearts. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1136756
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Jian…[et al.]. Preservation of Myocardial Perfusion and Function by Keeping Hypertrophied Heart Empty and Beating for Valve Surgery: An In Vivo MR Study of Pig Hearts. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1136756
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Jian& Xiang, Bo& Deng, Jixian& Lin, Hung-Yu& Freed, Darren H.& Arora, Rakesh C.…[et al.]. Preservation of Myocardial Perfusion and Function by Keeping Hypertrophied Heart Empty and Beating for Valve Surgery: An In Vivo MR Study of Pig Hearts. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1136756
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136756
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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