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Mechanistic Understanding of Cell Recognition and Immune Reaction via CR1CR3 by HAP- and SiO2-NPs
المؤلفون المشاركون
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-23
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Nanodrug carrier will eventually enter the blood when intravenously injected or in other ways.
Meanwhile, a series of toxic effects were caused to the body with the formation of nanoparticle protein corona.
In our studies, we try to reveal the recognition mechanism of nanoparticle protein corona by monocyte and the damage effect on immune cells by activated complement of hydroxyapatite nanoparticles (HAP-NPs) and silicon dioxide nanoparticles (SiO2-NPs).
So expressions of TLR4/CR1/CR were analyzed by flow cytometry (FCM) in order to illuminate the recognition mechanism of nanoparticle protein corona by monocyte.
And the expression of ROS, cytokines, adhesion molecules, and arachidonic acid was measured when THP-1 and HUVECs were stimulated by NP-activated complement.
The results showed that HAP-NPs can be recognized by the opsonin receptor (iC3b/CR3) model, while plasma protein, opsonin receptor, and Toll-like receptors are all likely launch cell recognition of SiO2-NPs.
And it was considerate that NP-activated complement can damage THP-1 and HUVECs, including oxidative stress, inflammation, and increased vascular permeability.
So the surface of nanodrug carrier can be modified to avoid being clear and reduce the efficacy according to the three receptors (TLR4/CR1/CR3).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ding, Tingting& Sun, Jiao. 2020. Mechanistic Understanding of Cell Recognition and Immune Reaction via CR1CR3 by HAP- and SiO2-NPs. BioMed Research International،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1136907
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ding, Tingting& Sun, Jiao. Mechanistic Understanding of Cell Recognition and Immune Reaction via CR1CR3 by HAP- and SiO2-NPs. BioMed Research International No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1136907
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ding, Tingting& Sun, Jiao. Mechanistic Understanding of Cell Recognition and Immune Reaction via CR1CR3 by HAP- and SiO2-NPs. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1136907
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136907
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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