Investigate the Effect of Thawing Process on the Self-Assembly of Silk Protein for Tissue Applications

المؤلفون المشاركون

Hiep, Nguyen Thi
Hai, Nguyen Dai
Luong, Hien Thu
Tran, Hien Anh
Huynh, Khon Chan
Toi, Vo Van

المصدر

BioMed Research International

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-16، 16ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-03-07

دولة النشر

مصر

عدد الصفحات

16

التخصصات الرئيسية

الطب البشري

الملخص EN

Biological self-assembly is a process in which building blocks autonomously organize to form stable supermolecules of higher order and complexity through domination of weak, noncovalent interactions.

For silk protein, the effect of high incubating temperature on the induction of secondary structure and self-assembly was well investigated.

However, the effect of freezing and thawing on silk solution has not been studied.

The present work aimed to investigate a new all-aqueous process to form 3D porous silk fibroin matrices using a freezing-assisted self-assembly method.

This study proposes an experimental investigation and optimization of environmental parameters for the self-assembly process such as freezing temperature, thawing process, and concentration of silk solution.

The optical images demonstrated the possibility and potential of −80ST48 treatment to initialize the self-assembly of silk fibroin as well as controllably fabricate a porous scaffold.

Moreover, the micrograph images illustrate the assembly of silk protein chain in 7 days under the treatment of −80ST48 process.

The surface morphology characterization proved that this method could control the pore size of porous scaffolds by control of the concentration of silk solution.

The animal test showed the support of silk scaffold for cell adhesion and proliferation, as well as the cell migration process in the 3D implantable scaffold.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Hiep, Nguyen Thi& Luong, Hien Thu& Hai, Nguyen Dai& Tran, Hien Anh& Huynh, Khon Chan& Toi, Vo Van. 2017. Investigate the Effect of Thawing Process on the Self-Assembly of Silk Protein for Tissue Applications. BioMed Research International،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1136909

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Hiep, Nguyen Thi…[et al.]. Investigate the Effect of Thawing Process on the Self-Assembly of Silk Protein for Tissue Applications. BioMed Research International No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1136909

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Hiep, Nguyen Thi& Luong, Hien Thu& Hai, Nguyen Dai& Tran, Hien Anh& Huynh, Khon Chan& Toi, Vo Van. Investigate the Effect of Thawing Process on the Self-Assembly of Silk Protein for Tissue Applications. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1136909

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1136909