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Effects of TLR3 and TLR9 Signaling Pathway on Brain Protection in Rats Undergoing Sevoflurane Pretreatment during Cardiopulmonary Bypass
المؤلفون المشاركون
Chen, Keyan
Nan, Zhou
Jin, Zhou
Huijuan, Cao
Tiezheng, Zhang
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the effects of TLR3 and TLR9 signaling pathway on brain injury during CPB in rats pretreated with sevoflurane and its possible molecular mechanism.
Methods.
SD rats were randomly assigned to sham group, CPB group, and Sev group.
Brain tissue was obtained at before CPB (T0), at CPB for 30 minutes (T1), 1 hour after CPB (T3), and 3 hours after CPB (T5).
ELISA was used to measure S100-β and IL-6.
Western blot was utilized to determine TLR3 and TLR9 expression.
TUNEL was applied to detect neuronal apoptosis.
Results.
Compared with CPB group, at T1, at termination after 1 hour of CPB (T2), T3, 2 hours after CPB (T4) and T5, S100-β and IL-6 decreased in Sev group.
Compared with CPB group, IFN-β were increased in Sev group, except T0.
Compared with CPB group, TLR3 expression increased, and TLR9 and NF-κB decreased in Sev group.
The apoptotic neurons were less in Sev group than in CPB group (P<0.05).
Conclusion.
Sevoflurane intervention can activate TLR3 and TLR9 signaling pathway, upregulate TLR3 expression and downstream TRIF expression, decrease TLR9 expression, and downregulate downstream NF-κB expression in CPB rat models, thereby mitigating brain injury induced by inflammatory response during CPB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nan, Zhou& Jin, Zhou& Huijuan, Cao& Tiezheng, Zhang& Chen, Keyan. 2017. Effects of TLR3 and TLR9 Signaling Pathway on Brain Protection in Rats Undergoing Sevoflurane Pretreatment during Cardiopulmonary Bypass. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136958
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nan, Zhou…[et al.]. Effects of TLR3 and TLR9 Signaling Pathway on Brain Protection in Rats Undergoing Sevoflurane Pretreatment during Cardiopulmonary Bypass. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1136958
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nan, Zhou& Jin, Zhou& Huijuan, Cao& Tiezheng, Zhang& Chen, Keyan. Effects of TLR3 and TLR9 Signaling Pathway on Brain Protection in Rats Undergoing Sevoflurane Pretreatment during Cardiopulmonary Bypass. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1136958
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136958
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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