Potential Efficacy of Erythropoietin on Reducing the Risk of Mortality in Patients with Traumatic Brain Injury: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Wang, Jiarui
Liu, Chengli
Huang, Changsheng
Xie, Jie
Hong, Michael
Li, Zhanfei
Wang, Jian
Wang, Wei
Li, Hui
Chen, Xuemei
Wang, Junmin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
The objective of this study is to assess the effectiveness of erythropoietin (EPO) on mortality, neurological outcomes, and adverse event in the treatment of traumatic brain injury (TBI).
Methods.
We searched databases including PubMed, OVID, and the Cochrane Library from inception until October 18, 2019 for randomized controlled trials (RCTs) to compare EPO treatment group and placebo in patients with TBI.
Two authors independently processed the data and evaluated the quality of inclusion studies.
Statistical analysis was performed with heterogeneity test with I2 and chi-square tests.
We summarized the mortality, prognosis of neurological function, and deep vein thrombosis (DVT) outcomes and presented as risk ratio (RR) or risk difference (RD) with a 95% CI.
Results.
Seven RCTs accounting for 1180 patients were included after meeting the inclusion criteria.
Compared with placebo, the overall mortality of EPO-treated patients was significantly reduced (RR 0.68 [95% CI 0.50-0.93]; p=0.02).
EPO therapy did not improve neurological prognosis (RR 1.21 [95% CI 0.93-1.15]; p=0.16) or increase the occurrence of DVT (RR 0.83 [95% CI 0.61–1.13]; p=0.242), which showed no significant difference.
Conclusions.
The results showed that the administration of EPO may reduce the risk of mortality without enhancing the occurrence of DVT in TBI patients.
However, the effect of EPO on neurological outcome remains indistinct.
Through subgroup analysis, we demonstrated that the dose of EPO may be a potential factor affecting the heterogeneity in neurological function and that the follow-up duration may influence the stability of the result.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Chengli& Huang, Changsheng& Xie, Jie& Li, Hui& Hong, Michael& Chen, Xuemei…[et al.]. 2020. Potential Efficacy of Erythropoietin on Reducing the Risk of Mortality in Patients with Traumatic Brain Injury: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136967
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Chengli…[et al.]. Potential Efficacy of Erythropoietin on Reducing the Risk of Mortality in Patients with Traumatic Brain Injury: A Systematic Review and Meta-Analysis. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1136967
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Chengli& Huang, Changsheng& Xie, Jie& Li, Hui& Hong, Michael& Chen, Xuemei…[et al.]. Potential Efficacy of Erythropoietin on Reducing the Risk of Mortality in Patients with Traumatic Brain Injury: A Systematic Review and Meta-Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136967
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136967
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر