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Association between Antihypertensive Drug Use and the Incidence of Cognitive Decline and Dementia: A Meta-Analysis of Prospective Cohort Studies
المؤلفون المشاركون
Wang, Qiongying
Liang, Qiang
Xu, Guangli
Bai, Feng
Lin, Xin
Wu, Qiang
Sun, Shougang
Jiang, Cheng
Gao, Bingren
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-28
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Antihypertensive drug use is inconsistently associated with the risk of dementia, Alzheimer’s disease, cognitive impairment, and cognitive decline.
Therefore, we conducted a meta-analysis of available prospective cohort studies to summarize the evidence on the strength of these relationships.
Methods.
Three electronic databases including MedLine, Embase, and the Cochrane Library were searched to identify studies from inception to April 2017.
Only prospective cohort studies that reported effect estimates with corresponding 95% confidence intervals (CIs) of dementia, Alzheimer’s disease, cognitive impairment, and cognitive decline for antihypertensive drug use versus not using antihypertensive drugs were included.
Results.
We included 10 prospective cohort studies reporting data on 30,895 individuals.
Overall, participants who received antihypertensive drugs had lower incidence of dementia (relative risk [RR]: 0.86; 95% CI: 0.75–0.99; p=0.033), while there was no significant effect on the incidence of Alzheimer’s disease (RR: 0.83; 95% CI: 0.64–1.09; p=0.154), cognitive impairment (RR: 0.89; 95% CI: 0.57–1.38; p=0.596), and cognitive decline (RR: 1.11; 95% CI: 0.86–1.43; p=0.415).
Further, the incidence of Alzheimer’s disease might be affected by antihypertensive drug use in participants with specific characteristics.
Conclusions.
Antihypertensive drug use was associated with a significantly reduced risk of dementia, but not with the risk of Alzheimer’s disease, cognitive impairment, and cognitive decline.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Guangli& Bai, Feng& Lin, Xin& Wang, Qiongying& Wu, Qiang& Sun, Shougang…[et al.]. 2017. Association between Antihypertensive Drug Use and the Incidence of Cognitive Decline and Dementia: A Meta-Analysis of Prospective Cohort Studies. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1137032
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Guangli…[et al.]. Association between Antihypertensive Drug Use and the Incidence of Cognitive Decline and Dementia: A Meta-Analysis of Prospective Cohort Studies. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1137032
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Guangli& Bai, Feng& Lin, Xin& Wang, Qiongying& Wu, Qiang& Sun, Shougang…[et al.]. Association between Antihypertensive Drug Use and the Incidence of Cognitive Decline and Dementia: A Meta-Analysis of Prospective Cohort Studies. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1137032
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137032
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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