CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD
المؤلفون المشاركون
Peng, Junming
Guo, Jinan
Xiao, Kefeng
Jiang, Hongtao
Huang, Jiansheng
Yuan, Qian
Xie, Jing
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
CD147, also known as BSG, is a type I transmembrane glycoprotein that belonged to immunoglobulin superfamily.
Mature CD147 is an N-linked glycosylated protein and exists on the transmembrane and as soluble forms in tumors.
However, the function of CD147 in cell proliferation of bladder cancer (BC) remains to be elucidated.
Methods.
The study included 159 patients with BC and 68 healthy controls.
The expression of CD147 and gasdermin D (GSDMD) was analyzed by immunohistochemistry (IHC).
Western blotting was performed to detect the expression of proteins in BC cells.
The relationship between CD147 and GSDMD was analyzed by the IHC score.
Results.
The expression of CD147 was significantly increased in BC when compared to healthy controls, and the level of CD147 was correlated with tumor proliferation characterized by Ki-67, which is a cell proliferation antigen.
In addition, CD147 treatment of BC cells increased the expression of GSDMD, leading to increased Ki-67 expression, while CD147 blockade with peptide in BC significantly reduced GSDMD expression, resulting in reduced cell proliferation.
Furthermore, overexpression of GSDMD markedly overcame the inhibitory effect of CD147 peptide on tumor proliferation.
BC patients with overexpression of CD147 showed correlation with GSDMD and demonstrated significantly poorer prognosis and overall survival rate.
Conclusion.
These findings suggested that high expression of CD147 contributed to tumor proliferation in BC via GSDMD, which might in turn act as an unfavorable prognostic marker.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Peng, Junming& Jiang, Hongtao& Guo, Jinan& Huang, Jiansheng& Yuan, Qian& Xie, Jing…[et al.]. 2020. CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1137083
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Peng, Junming…[et al.]. CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1137083
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Peng, Junming& Jiang, Hongtao& Guo, Jinan& Huang, Jiansheng& Yuan, Qian& Xie, Jing…[et al.]. CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1137083
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137083
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر