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Early Diagnosis of Latent Tuberculosis Reactivation due to Drug Interaction between Cobicistat and Intranasal Fluticasone
المؤلفون المشاركون
Pineda-Reyes, Roberto
Klochko, Alena
المصدر
Case Reports in Infectious Diseases
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-03
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Background.
Single-tablet antiretroviral therapy is currently the first-line choice for the treatment of HIV infection.
Some therapeutic regimens contain the CYP3A4 inhibitor cobicistat, which can interact with drugs undergoing hepatic first-pass metabolism, leading to unintended adverse effects.
Case Presentation.
A 41-year-old man presented to the HIV clinic following a visit to the Emergency Department.
His CD4+ count was 1,271 cells/μL, and viral load was undetectable in the previous month.
The patient was on an antiretroviral therapy regimen containing cobicistat.
He reported using a self-initiated over-the-counter fluticasone nasal spray for at least 2 weeks prior.
He had a history of positive tuberculin skin test and a negative chest X-ray within the past year.
He denied cough and was in no respiratory distress.
A chest CT scan revealed a new thick-walled cavitary nodule in the right upper lobe.
A CT-guided biopsy of the lesion yielded Mycobacterium tuberculosis.
Conclusions.
HIV-infected individuals have higher risk for tuberculosis reactivation regardless of their CD4+ count.
Fluticasone’s hepatic metabolism is bypassed in the presence of CYP3A4 inhibitors, which increases its systemic bioavailability and the risk for impaired immunity.
The goal of this report is to increase awareness among physicians about the potential adverse outcomes from the interaction of these drugs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pineda-Reyes, Roberto& Klochko, Alena. 2019. Early Diagnosis of Latent Tuberculosis Reactivation due to Drug Interaction between Cobicistat and Intranasal Fluticasone. Case Reports in Infectious Diseases،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1137141
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pineda-Reyes, Roberto& Klochko, Alena. Early Diagnosis of Latent Tuberculosis Reactivation due to Drug Interaction between Cobicistat and Intranasal Fluticasone. Case Reports in Infectious Diseases No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1137141
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pineda-Reyes, Roberto& Klochko, Alena. Early Diagnosis of Latent Tuberculosis Reactivation due to Drug Interaction between Cobicistat and Intranasal Fluticasone. Case Reports in Infectious Diseases. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1137141
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137141
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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