MicroRNA Mediating Networks in Granulosa Cells Associated with Ovarian Follicular Development
المؤلفون المشاركون
Zhang, Baoyun
Chen, Long
Feng, Guangde
Xiang, Wei
Zhang, Ke
Chu, Mingxing
Wang, Pingqing
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-19
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Ovaries, which provide a place for follicular development and oocyte maturation, are important organs in female mammals.
Follicular development is complicated physiological progress mediated by various regulatory factors including microRNAs (miRNAs).
To demonstrate the role of miRNAs in follicular development, this study analyzed the expression patterns of miRNAs in granulosa cells through investigating three previous datasets generated by Illumina miRNA deep sequencing.
Furthermore, via bioinformatic analyses, we dissected the associated functional networks of the observed significant miRNAs, in terms of interacting with signal pathways and transcription factors.
During the growth and selection of dominant follicles, 15 dysregulated miRNAs and 139 associated pathways were screened out.
In comparison of different styles of follicles, 7 commonly abundant miRNAs and 195 pathways, as well as 10 differentially expressed miRNAs and 117 pathways in dominant follicles in comparison with subordinate follicles, were collected.
Furthermore, SMAD2 was identified as a hub factor in regulating follicular development.
The regulation of miR-26a/b on smad2 messenger RNA has been further testified by real time PCR.
In conclusion, we established functional networks which play critical roles in follicular development including pivotal miRNAs, pathways, and transcription factors, which contributed to the further investigation about miRNAs associated with mammalian follicular development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Baoyun& Chen, Long& Feng, Guangde& Xiang, Wei& Zhang, Ke& Chu, Mingxing…[et al.]. 2017. MicroRNA Mediating Networks in Granulosa Cells Associated with Ovarian Follicular Development. BioMed Research International،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1137142
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Baoyun…[et al.]. MicroRNA Mediating Networks in Granulosa Cells Associated with Ovarian Follicular Development. BioMed Research International No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1137142
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Baoyun& Chen, Long& Feng, Guangde& Xiang, Wei& Zhang, Ke& Chu, Mingxing…[et al.]. MicroRNA Mediating Networks in Granulosa Cells Associated with Ovarian Follicular Development. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1137142
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137142
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر