Jacalin Has Chemopreventive Effects on Colon Cancer Development
المؤلفون المشاركون
Garcia, Sergio Britto
Pereira-da-Silva, Gabriela
Chain Veronez, Luciana
Herrero Geraldino, Thais
Modiano, Patricia
Flória-Santos, Milena
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-06
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Colorectal cancer, which is one of the most common causes of cancer-related deaths worldwide, has a slow natural history that provides a great opportunity for prevention strategies.
Plant-derived natural products have received considerable attention because of their inherent colorectal cancer chemopreventive effects.
The plant lectin jacalin specifically recognizes the tumor-associated Thomsen-Friedenreich antigen and has antiproliferative effects on human colon cancer cells, highlighting its potential antitumor activity.
To evaluate jacalin’s potential application in colorectal cancer chemoprevention, we studied its effects on the early stages of carcinogenesis.
Balb/c mice were given 4 intrarectal deposits of 0.1 ml solution of Methyl-N′-Nitro-N-Nitroso-Guanidine (5 mg/ml) twice a week (with a 3-day interval) for 2 weeks.
Starting 2 weeks before carcinogen administration, animals were treated orally with jacalin (0.5 and 25 μg) three times a week (on alternate weekdays) for 10 weeks.
We show that jacalin treatment reduced the number of preneoplastic lesions in carcinogen-exposed mice.
This anticarcinogenic activity was associated with decreased colonic epithelial cell proliferation and stromal COX-2 expression and with increased intestinal production of TNF-α.
Our results demonstrate that jacalin is able to modulate the early stages of colon carcinogenesis and emphasize its promising chemopreventive activity in colorectal cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Herrero Geraldino, Thais& Modiano, Patricia& Chain Veronez, Luciana& Flória-Santos, Milena& Garcia, Sergio Britto& Pereira-da-Silva, Gabriela. 2017. Jacalin Has Chemopreventive Effects on Colon Cancer Development. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1137192
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Herrero Geraldino, Thais…[et al.]. Jacalin Has Chemopreventive Effects on Colon Cancer Development. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1137192
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Herrero Geraldino, Thais& Modiano, Patricia& Chain Veronez, Luciana& Flória-Santos, Milena& Garcia, Sergio Britto& Pereira-da-Silva, Gabriela. Jacalin Has Chemopreventive Effects on Colon Cancer Development. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1137192
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137192
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر