MicroRNA-Related Prognosis Biomarkers from High-Throughput Sequencing Data of Colorectal Cancer
المؤلفون المشاركون
Zhu, Ning
Xing, Xiaoliang
Zhang, Ti
Yao, Zhi-Yong
Liu, Yuan-Wu
Peng, Jing
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-10
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Colorectal cancer (CRC) is the third most common cancer in the world, and most of them are adenocarcinomas.
CRC could be classified as colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) according to the original tumorigenesis position.
Increasing evidences indicated that microRNAs (miRNAs) play an important role in the occurrence of multiple tumors.
Methods.
In this study, we firstly downloaded miRNA (COAD, 8 controls vs.
455 tumors; READ, 3 controls vs.
161 tumors) and mRNA (COAD, 41 controls vs.
478 tumors; READ, 10 controls vs.
166 tumors) data from The Cancer Genome Atlas (TCGA) database and then used DESeq2, RegParallel, miRDB, TargetScanHuman 7.2, DAVID 6.8, STRING, and Cytoscape software to identify the potential prognosis biomarkers.
Results.
We identified 175 differential expression miRNAs (DEMs) and 3747 differential expression genes (DEGs) in COAD and 184 DEMs and 3928 DEGs in READ.
And then, we obtained 21 (13 in COAD and 8 in READ) DEMs associated with the survival rates, which correlated with 440 (217 in COAD and 223 in READ) overlapping DEGs.
Through survival analysis for those overlapping DEGs, we found 11 (8 in COAD and 3 in READ) overlapping DGEs associated with survival rates of patients, which were correlated with 9 (7 in COAD and 2 in READ) DEMs significantly.
Conclusion.
In this study, we found several candidate prognostic biomarkers which have been identified in various cancers and also found several new prognosis biomarkers of COAD and READ.
In conclusion, this analysis based on theoretical knowledge and clinical outcomes we have done needs further confirmation by more researches.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xing, Xiaoliang& Yao, Zhi-Yong& Zhang, Ti& Zhu, Ning& Liu, Yuan-Wu& Peng, Jing. 2020. MicroRNA-Related Prognosis Biomarkers from High-Throughput Sequencing Data of Colorectal Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137218
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xing, Xiaoliang…[et al.]. MicroRNA-Related Prognosis Biomarkers from High-Throughput Sequencing Data of Colorectal Cancer. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1137218
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xing, Xiaoliang& Yao, Zhi-Yong& Zhang, Ti& Zhu, Ning& Liu, Yuan-Wu& Peng, Jing. MicroRNA-Related Prognosis Biomarkers from High-Throughput Sequencing Data of Colorectal Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137218
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137218
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر