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Interactions of Consanguinity and Number of Siblings with Childhood Acute Lymphoblastic Leukemia
المؤلفون المشاركون
Kakaje, Ameer
Alhalabi, Mohammad Marwan
Ghareeb, Ayham
Karam, Bahjat
Mansour, Bassam
Zahra, Bayan
Hamdan, Othman
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-08
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Acute lymphoblastic leukemia (ALL) is a common malignancy in children.
Consanguinity has a high prevalence in developing countries and increases the probability of homozygosity for many genes which may affect ALL and its prognosis.
We conducted a study to explore the impact of consanguinity and number of siblings on ALL as there are currently no studies to describe this effect.
Data were collected from patients’ records from the Children’s University Hospital of Damascus University, which is the major cancer centre for children in Syria.
This study included 193 children with ALL over one year.
Number of siblings was not with the French–American–British (FAB) classification, gender, ALL subtype, or risk of ALL children.
When comparing consanguinity degrees and complete blood counts at diagnosis, significant contradicting data were found in the third-degree and fourth-degree consanguinity when compared to one another and to not having consanguineous parents as third degree consanguinity was associated with normal platelets but lower WBC counts, and fourth-degree consanguinity was associated with normal haemoglobin levels and WBC counts, but lower platelet counts.
Having consanguineous parents was also associated with acquiring ALL at an older age, L2 FAB classification, having a positive family history for malignancies, and not having hepatosplenomegaly (P<0.05).
Although L2 is known to be a poor prognosis indicatory, no association was found with consanguinity and risk.
Finally, no association was found with ALL subtype or risk (P>0.05).
Although consanguinity and number of siblings have affected some variables and prognostic features of childhood ALL, the aetiology is not clear and we need further studies to clarify such an association as this will help in optimising therapy and accurately determine the risk.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kakaje, Ameer& Alhalabi, Mohammad Marwan& Ghareeb, Ayham& Karam, Bahjat& Mansour, Bassam& Zahra, Bayan…[et al.]. 2020. Interactions of Consanguinity and Number of Siblings with Childhood Acute Lymphoblastic Leukemia. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1137237
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kakaje, Ameer…[et al.]. Interactions of Consanguinity and Number of Siblings with Childhood Acute Lymphoblastic Leukemia. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1137237
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kakaje, Ameer& Alhalabi, Mohammad Marwan& Ghareeb, Ayham& Karam, Bahjat& Mansour, Bassam& Zahra, Bayan…[et al.]. Interactions of Consanguinity and Number of Siblings with Childhood Acute Lymphoblastic Leukemia. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1137237
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137237
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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