Anti-inflammatory, Antibacterial, Toxicological Profile, and In Silico Studies of Dimeric Naphthoquinones from Diospyros lotus
المؤلفون المشاركون
Rauf, Abdur
Abu-Izneid, Tareq
Rashid, Umer
Alhumaydhi, Fahad A.
Bawazeer, Saud
Khalil, Anees Ahmed
Aljohani, Abdullah S. M.
Abdallah, Emad M.
Al-Tawaha, Abdel Rahman
Mabkhot, Yahia Naseer
Shariati, Mohammad Ali
Plygun, Sergey
Uddin, Md. Sahab
Ntsefong, Godswill Ntsomboh
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Diospyros lotus, also known as date-plum, belongs to the Ebenaceae family and is mostly recognized as a rootstock for D.
kaki.
Similar classes of naphthoquinones in D.
lotus are investigated against cancer and inflammation and have antimicrobial, sedative, and analgesic properties.
Six chemical constituents (1-6) were isolated from Diospyros lotus and tested for anti-inflammatory effects at the dose of 2.5 and 5 mg/kg, i.p., using carrageenan (1%, 0.05 ml)-induced paw edema.
The maximum protection against carrageenan-induced edema was observed for compounds 1 and 2.
Both studied compounds demonstrated significant anti-inflammatory effect after the 3rd hour of posttreatment.
The maximum anti-inflammatory effect of compound 1 was 85.96%, while that of compound 2 was 81.44%, followed by compounds 5 and 6, which exhibited 80.11% and 82.45% effect, respectively.
Similarly, histamine-induced inflammation was significantly antagonized by 1, 2, 5, and 6 with 87.99%, 82.18±1.8, 80.40±1.59, and 77.44% effects, respectively, at 5 mg/kg after the 2nd hour of posttreatment.
The rest of the tested compounds did not show any significant effect as compared to the negative control.
Interestingly, no toxicity was observed at higher doses.
Moreover, the extracted compounds showed remarkable antibacterial activity against the Gram-positive bacteria and no effect against the Gram-negative bacteria.
Docking studies on target cyclooxygenases showed that all the compounds established interactions with the key amino acid residues present in the additional pocket of COX-2.
Hence, these compounds may act as selective COX-2 inhibitors.
In conclusion, the findings of the current study suggest that the roots of Diospyros lotus may contain some anti-inflammatory and antibacterial agents with minimal toxicological effects and accordingly this plant product is recommended for further investigations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rauf, Abdur& Abu-Izneid, Tareq& Rashid, Umer& Alhumaydhi, Fahad A.& Bawazeer, Saud& Khalil, Anees Ahmed…[et al.]. 2020. Anti-inflammatory, Antibacterial, Toxicological Profile, and In Silico Studies of Dimeric Naphthoquinones from Diospyros lotus. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1137265
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rauf, Abdur…[et al.]. Anti-inflammatory, Antibacterial, Toxicological Profile, and In Silico Studies of Dimeric Naphthoquinones from Diospyros lotus. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1137265
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rauf, Abdur& Abu-Izneid, Tareq& Rashid, Umer& Alhumaydhi, Fahad A.& Bawazeer, Saud& Khalil, Anees Ahmed…[et al.]. Anti-inflammatory, Antibacterial, Toxicological Profile, and In Silico Studies of Dimeric Naphthoquinones from Diospyros lotus. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1137265
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137265
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر