Pharmacokinetics, Tissue Distribution, and Metabolism Study of Icariin in Rat

المؤلفون المشاركون

Xu, Shunjun
Yang, Liu
Yu, Jiejing
Zhan, Jingjing
Guo, Longgang
Xu, Yijuan

المصدر

BioMed Research International

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-17، 17ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-11-13

دولة النشر

مصر

عدد الصفحات

17

التخصصات الرئيسية

الطب البشري

الملخص EN

Icariin is one of the predominant flavonoids contained in Herba Epimedii (Yin-yang-huo in Chinese), a well-known Chinese medicine for the treatment of cancers and immune system diseases.

Although Herba Epimedii has been widely used in China and there are so many and various research reports on the herbal drug and its main flavones, very limited data is available on the tissue distribution and biotransformation of icariin.

In the present study, a liquid chromatographic method combined with electrospray ionization tandem mass spectrometry was developed to quantify the concentration of icariin in rat plasma and various tissues collected at different time points after oral administration of the total flavonoid extract of Herba Epimedii at a dose of 0.69 g/kg (corresponding to 42 mg/g icariin).

Biological samples were processed by simple protein precipitation.

Genistein was chosen as internal standard.

The method was successfully applied to plasma pharmacokinetic and tissue distribution studies of icariin in rat.

As a result, it was worth noting that the tissue distribution characteristics of icariin exhibited a significant gender difference.

Moreover, in vivo metabolism of icariin was also investigated.

A total of 11 potential metabolites were found in rat feces collected in different time periods after oral and intramuscular administration of icariin.

In vivo metabolic pathways were involved in hydrolysis, demethylation, oxidation, and conjugation.

The preclinical data would be useful for fully understanding in vivo disposition of this compound and interpreting the mechanism of its biological response.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Xu, Shunjun& Yu, Jiejing& Zhan, Jingjing& Yang, Liu& Guo, Longgang& Xu, Yijuan. 2017. Pharmacokinetics, Tissue Distribution, and Metabolism Study of Icariin in Rat. BioMed Research International،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1137306

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Xu, Shunjun…[et al.]. Pharmacokinetics, Tissue Distribution, and Metabolism Study of Icariin in Rat. BioMed Research International No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1137306

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Xu, Shunjun& Yu, Jiejing& Zhan, Jingjing& Yang, Liu& Guo, Longgang& Xu, Yijuan. Pharmacokinetics, Tissue Distribution, and Metabolism Study of Icariin in Rat. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1137306

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1137306