Iron-Chelating Agent Can Maintain Bone Homeostasis Disrupted by Iron Overload by Upregulating WntBeta-Catenin Signaling
المؤلفون المشاركون
Chen, Yu
Yu, Ronghua
Xu, Wei
Zhu, Xiaodong
Li, Zhikun
Jia, Jianjun
Li, Dachuan
Zhang, Xiangyang
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The incidence of osteoporotic fractures is increasing.
In this study, we explored the activities of Wnt/β-catenin signaling in bone tissues with iron accumulation.
Methods.
We established rat bipedal walking models (RBWM), and a portion of our RBWM rats were intraperitoneally injected with ferric ammonium citrate, normal saline, and deferoxamine.
Bone mineral density was measured with a small animal in vivo imaging system.
The protein levels of ferritin, TRAP-5B, RANKL, and OPG in serum were measured by the enzyme-linked immunosorbent assay (ELISA).
Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot were used to quantify the RNA and protein expression levels of certain regulators involved in Wnt/β-catenin signaling in bone tissues.
Results.
In the present study, we established a rat bipedal walking model containing 32 bipedal rats, which were randomly classified into four groups, termed as NS, FAC, FAC+NS, and FAC+DFO.
Those three experimental groups with FAC injection had significantly lower bone mineral density (BMD) than the control group NS (P<0.05).
The disruption of bone homeostasis and downregulation of Wnt/β-catenin signaling were also observed in the three groups with FAC injection.
Moreover, after the injection of deferoxamine, those aberrations in samples with FAC injection seemed repaired as test results returning or getting close to normal ranges.
Conclusion.
The osteoporosis could be caused by iron overload, which reduced the bone mineral density by disrupting the homeostasis of bone formation and absorption and attenuating the Wnt/β-catenin signaling in bone tissues.
The deferoxamine had the potential to improve the bone health by reducing the accumulation of iron and increasing the bone mass, which might be a promising therapeutic solution for osteoporosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Wei& Yu, Ronghua& Zhu, Xiaodong& Li, Zhikun& Jia, Jianjun& Li, Dachuan…[et al.]. 2020. Iron-Chelating Agent Can Maintain Bone Homeostasis Disrupted by Iron Overload by Upregulating WntBeta-Catenin Signaling. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137374
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Wei…[et al.]. Iron-Chelating Agent Can Maintain Bone Homeostasis Disrupted by Iron Overload by Upregulating WntBeta-Catenin Signaling. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1137374
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Wei& Yu, Ronghua& Zhu, Xiaodong& Li, Zhikun& Jia, Jianjun& Li, Dachuan…[et al.]. Iron-Chelating Agent Can Maintain Bone Homeostasis Disrupted by Iron Overload by Upregulating WntBeta-Catenin Signaling. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137374
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137374
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر