Evaluation of Immunosuppressive Therapy Use for Tracheal Transplantation with Trachea-Mimetic Bellows Scaffolds in a Rabbit Model
المؤلفون المشاركون
Kang, Seong Soo
Kim, Gonhyung
Lee, Jae Yeon
Son, Soo Jin
Kim, Gonhyung
Park, Jeong Hun
Han, Mina
Cho, Dong-Woo
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-26
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The objective of this study was to evaluate the use of immunosuppressive therapy with high-dose cyclosporine, high-dose azathioprine, and a combination of low-dose cyclosporine and azathioprine after tracheal reconstruction by using a trachea-mimetic graft of polycaprolactone (PCL) bellows-type scaffold in a rabbit model.
Twenty-four healthy New Zealand white rabbits were used in the study.
All underwent circumferential tracheal replacement using tissue-engineered tracheal graft, prepared from PCL bellows scaffold reinforced with silicone ring, collagen hydrogel, and human turbinate mesenchymal stromal cell (hTMSC) sheets.
The control group (Group 1) received no medication.
The three experimental groups were given daily cyclosporine intramuscular doses of 10 mg/kg (Group 2), azathioprine oral doses of 5 mg/kg (Group 3), and azathioprine oral doses of 2.5 mg/kg plus cyclosporine intramuscular doses of 5 mg/kg (Group 4) for 4 weeks or until death.
Group 1 had longer survival times compared to Group 2 or Group 3.
Each group except for Group 1 experienced decreases in amount of nutrition and weight loss.
In addition, compared with the other groups, Group 2 had significantly increased serum interleukin-2 and interferon-γ levels 7 days after transplantation.
The results of this study showed that the administration of cyclosporine and/or azathioprine after tracheal transplantation had no beneficial effects.
Furthermore, the administration of cyclosporine had side effects, including extreme weight loss, respiratory distress, and diarrhea.
Therefore, cyclosporine and azathioprine avoidance may be recommended for tracheal reconstruction using a native trachea-mimetic graft of PCL bellows-type scaffold in a rabbit model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Jae Yeon& Park, Jeong Hun& Son, Soo Jin& Han, Mina& Kim, Gonhyung& Kang, Seong Soo…[et al.]. 2017. Evaluation of Immunosuppressive Therapy Use for Tracheal Transplantation with Trachea-Mimetic Bellows Scaffolds in a Rabbit Model. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1137489
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Jae Yeon…[et al.]. Evaluation of Immunosuppressive Therapy Use for Tracheal Transplantation with Trachea-Mimetic Bellows Scaffolds in a Rabbit Model. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1137489
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Jae Yeon& Park, Jeong Hun& Son, Soo Jin& Han, Mina& Kim, Gonhyung& Kang, Seong Soo…[et al.]. Evaluation of Immunosuppressive Therapy Use for Tracheal Transplantation with Trachea-Mimetic Bellows Scaffolds in a Rabbit Model. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1137489
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137489
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر