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Smoking, Gender, and Overweight Are Important Influencing Factors on Monocytic HLA-DR before and after Major Cancer Surgery
المؤلفون المشاركون
Spies, Claudia D.
von Haefen, Clarissa
Wernecke, Klaus-Dieter
Lachmann, Gunnar
Kurth, Johannes
Yuerek, Fatima
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Monocytic human leukocyte antigen D related (mHLA-DR) is essential for antigen-presentation.
Downregulation of mHLA-DR emerged as a general biomarker of impaired immunity seen in patients with sepsis and pneumonia and after major surgery.
Influencing factors of mHLA-DR such as age, overweight, diabetes, smoking, and gender remain unclear.
Methods.
We analyzed 20 patients after esophageal or pancreatic resection of a prospective, randomized, placebo-controlled, double-blind trial (placebo group).
mHLA-DR was determined from day of surgery (od) until postoperative day (pod) 5.
Statistical analyses were performed using multivariate generalized estimating equation analyses (GEE), nonparametric multivariate analysis of longitudinal data, and univariate post hoc nonparametric Mann–Whitney tests.
Results.
In GEE, smoking and gender were confirmed as significant influencing factors over time.
Univariate analyses of mHLA-DR between smokers and nonsmokers showed lower preoperative levels (p=0.010) and a trend towards lower levels on pod5 (p=0.056) in smokers.
Lower mHLA-DR was seen in men on pod3 (p=0.038) and on pod5 (p=0.026).
Overweight patients (BMI > 25 kg/m2) had lower levels of mHLA-DR on pod3 (p=0.039) and pod4 (p=0.047).
Conclusion.
Smoking is an important influencing factor on pre- and postoperative immune function while postoperative immune function was influenced by gender and overweight.
Clinical trial registered with ISRCTN27114642.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lachmann, Gunnar& von Haefen, Clarissa& Kurth, Johannes& Yuerek, Fatima& Wernecke, Klaus-Dieter& Spies, Claudia D.. 2017. Smoking, Gender, and Overweight Are Important Influencing Factors on Monocytic HLA-DR before and after Major Cancer Surgery. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1137498
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lachmann, Gunnar…[et al.]. Smoking, Gender, and Overweight Are Important Influencing Factors on Monocytic HLA-DR before and after Major Cancer Surgery. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1137498
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lachmann, Gunnar& von Haefen, Clarissa& Kurth, Johannes& Yuerek, Fatima& Wernecke, Klaus-Dieter& Spies, Claudia D.. Smoking, Gender, and Overweight Are Important Influencing Factors on Monocytic HLA-DR before and after Major Cancer Surgery. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1137498
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137498
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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