Helicobacter pylori from Peptic Ulcer Patients in Uganda Is Highly Resistant to Clarithromycin and Fluoroquinolones: Results of the GenoType HelicoDR Test Directly Applied on Stool
المؤلفون المشاركون
Angol, Denish Calmax
Ocama, Ponsiano
Ayazika Kirabo, Tess
Okeng, Alfred
Najjingo, Irene
Bwanga, Freddie
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Around 70–90% of peptic ulcer disease (PUD) is due to Helicobacter pylori and requires treatment with antimicrobials to which these bacteria are susceptible.
Common H.
pylori diagnostic tests do not provide drug susceptibility data.
Using the GenoType HelicoDR PCR test designed for gastric biopsies for simultaneous detection of H.
pylori and its resistance to clarithromycin (CLA)/fluoroquinolones (FLQ), we present evidence for stool as an optional test specimen and also provide data on prevalence of H.
pylori resistance to CLA and FLQ in Uganda.
Methods.
Stool from 142 symptomatic PUD patients at three hospitals in Kampala was screened for H.
pylori using a rapid antigen test.
The GenoType HelicoDR test was run on all H.
pylori antigen positives to determine PCR positivity and resistance to CLA/FLQ.
Results.
Thirty-one samples (22%) were H.
pylori antigen positive, and 21 (68%) of these were H.
pylori PCR positive.
Six of the 21 (29%) were resistant to CLA and eight to FLQ (42%), while two gave invalid FLQ resistance results.
Conclusion.
Stool is a possible specimen for the GenoType HelicoDR test for rapid detection of H.
pylori and drug resistance.
In Uganda, Helicobacter pylori is highly resistant to CLA and FLQ.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Angol, Denish Calmax& Ocama, Ponsiano& Ayazika Kirabo, Tess& Okeng, Alfred& Najjingo, Irene& Bwanga, Freddie. 2017. Helicobacter pylori from Peptic Ulcer Patients in Uganda Is Highly Resistant to Clarithromycin and Fluoroquinolones: Results of the GenoType HelicoDR Test Directly Applied on Stool. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137626
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Angol, Denish Calmax…[et al.]. Helicobacter pylori from Peptic Ulcer Patients in Uganda Is Highly Resistant to Clarithromycin and Fluoroquinolones: Results of the GenoType HelicoDR Test Directly Applied on Stool. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1137626
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Angol, Denish Calmax& Ocama, Ponsiano& Ayazika Kirabo, Tess& Okeng, Alfred& Najjingo, Irene& Bwanga, Freddie. Helicobacter pylori from Peptic Ulcer Patients in Uganda Is Highly Resistant to Clarithromycin and Fluoroquinolones: Results of the GenoType HelicoDR Test Directly Applied on Stool. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137626
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137626
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر