Cardiac Optogenetics in Atrial Fibrillation: Current Challenges and Future Opportunities
المؤلفون المشاركون
Floria, Mariana
Radu, Smaranda
Gosav, Evelina Maria
Moraru, Aurelian Corneliu
Serban, Teodor
Carauleanu, Alexandru
Costea, Claudia Florida
Ouatu, Anca
Ciocoiu, Manuela
Tanase, Daniela Maria
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-27
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Although rarely life-threatening on short term, atrial fibrillation leads to increased mortality and decreased quality of life through its complications, including heart failure and stroke.
Recent studies highlight the benefits of maintaining sinus rhythm.
However, pharmacological long-term rhythm control strategies may be shadowed by associated proarrhythmic effects.
At the same time, electrical cardioversion is limited to hospitals, while catheter ablation therapy, although effective, is invasive and is dedicated to specific patients, usually with low amounts of atrial fibrosis (preferably Utah I-II).
Cardiac optogenetics allows influencing the heart’s electrical activity by applying specific wavelength light pulses to previously engineered cardiomyocytes into expressing microbial derived light-sensitive proteins called opsins.
The resulting ion influx may give rise to either hyperpolarizing or depolarizing currents, thus offering a therapeutic potential in cardiac electrophysiology, including pacing, resynchronization, and arrhythmia termination.
Optogenetic atrial fibrillation cardioversion might be achieved by inducing a conduction block or filling of the excitable gap.
The authors agree that transmural opsin expression and appropriate illumination with an exposure time longer than the arrhythmia cycle length are necessary to achieve successful arrhythmia termination.
However, the efficiency and safety of biological cardioversion in humans remain to be seen, as well as side effects such as immune reactions and loss of opsin expression.
The possibility of delivering pain-free shocks with out-of-hospital biological cardioversion is tempting; however, there are several issues that need to be addressed first: applicability and safety in humans, long-term behaviour, anticoagulation requirements, and fibrosis interactions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Floria, Mariana& Radu, Smaranda& Gosav, Evelina Maria& Moraru, Aurelian Corneliu& Serban, Teodor& Carauleanu, Alexandru…[et al.]. 2020. Cardiac Optogenetics in Atrial Fibrillation: Current Challenges and Future Opportunities. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1137675
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Floria, Mariana…[et al.]. Cardiac Optogenetics in Atrial Fibrillation: Current Challenges and Future Opportunities. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1137675
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Floria, Mariana& Radu, Smaranda& Gosav, Evelina Maria& Moraru, Aurelian Corneliu& Serban, Teodor& Carauleanu, Alexandru…[et al.]. Cardiac Optogenetics in Atrial Fibrillation: Current Challenges and Future Opportunities. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1137675
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137675
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر