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Electrical Stimulation of Denervated Rat Skeletal Muscle Retards Capillary and Muscle Loss in Early Stages of Disuse Atrophy
المؤلفون المشاركون
Nakagawa, Kouki
Tamaki, Hiroyuki
Hayao, Keishi
Yotani, Kengo
Ogita, Futoshi
Yamamoto, Noriaki
Onishi, Hideaki
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The purpose of the present study is to investigate the effects of low-frequency electrical muscle stimulation (ES) on the decrease in muscle mass, fiber size, capillary supply, and matrix metalloproteinase (MMP) immunoreactivity in the early stages of denervation-induced limb disuse.
Direct ES was performed on the tibialis anterior muscle following denervation in seven-week-old male rats.
The rats were divided into the following groups: control (CON), denervation (DN), and denervation with direct ES (DN + ES).
Direct ES was performed at an intensity of 16 mA and a frequency of 10 Hz for 30 min per day, six days a week, for one week.
We performed immunohistochemical staining to determine the expression of dystrophin, CD34, and MMP-2 in transverse sections of TA muscles.
The weight, myofiber cross-sectional area (FCSA), and capillary-to-fiber (C/F) ratio of the tibialis anterior (TA) muscle were significantly reduced in the DN group compared to the control and DN + ES groups.
The MMP-2 positive area was significantly greater in DN and DN + ES groups compared to the control group.
These findings suggest beneficial effects of direct ES in reducing muscle atrophy and capillary regression without increasing MMP-2 immunoreactivity in the early stages of DN-induced muscle disuse in rat hind limbs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nakagawa, Kouki& Tamaki, Hiroyuki& Hayao, Keishi& Yotani, Kengo& Ogita, Futoshi& Yamamoto, Noriaki…[et al.]. 2017. Electrical Stimulation of Denervated Rat Skeletal Muscle Retards Capillary and Muscle Loss in Early Stages of Disuse Atrophy. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137709
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nakagawa, Kouki…[et al.]. Electrical Stimulation of Denervated Rat Skeletal Muscle Retards Capillary and Muscle Loss in Early Stages of Disuse Atrophy. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1137709
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nakagawa, Kouki& Tamaki, Hiroyuki& Hayao, Keishi& Yotani, Kengo& Ogita, Futoshi& Yamamoto, Noriaki…[et al.]. Electrical Stimulation of Denervated Rat Skeletal Muscle Retards Capillary and Muscle Loss in Early Stages of Disuse Atrophy. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137709
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137709
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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