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GJA1 Expression and Its Prognostic Value in Cervical Cancer
المؤلفون المشاركون
Zhang, Jianwei
An, Ran
Meng, Silu
Fan, Xinran
Li, Shuang
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Gap Junction Protein Alpha 1 (GJA1) belongs to the gap junction family and has been widely studied in cancers.
We evaluated the role of GJA1 in cervical cancer (CC) using public data from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database.
The difference of GJA1 expression level between CC and normal tissues was analyzed by the Gene Expression Profiling Interactive Analysis (GEPIA), six GEO datasets, and the Human Protein Atlas (HPA).
The relationship between clinicopathological features and GJA1 expression was analyzed by the chi-squared test and the logistic regression.
Kaplan–Meier survival analysis and Cox proportional hazard regression analysis were used to assessing the effect of GJA1 expression on survival.
Gene set enrichment analysis (GSEA) was used to screen the signaling pathways regulated by GJA1.
Immune Cell Abundance Identifier (ImmuCellAI) was chosen to analyze the immune cells affected by GJA1.
The expression of GJA1 in CC was significantly lower than that in normal tissues based on the GEPIA, GEO datasets, and HPA.
Both the chi-squared test and the logistic regression showed that high-GJA1 expression was significantly correlated with keratinization, hormone use, tumor size, and FIGO stage.
The Kaplan–Meier curves suggested that high-GJA1 expression could indicate poor prognosis (p=0.0058).
Multivariate analysis showed that high-GJA1 expression was an independent predictor of poor overall survival (HR, 4.084; 95% CI, 1.354-12.320; p=0.013).
GSEA showed many cancer-related pathways, such as the p53 signaling pathway and the Wnt signaling pathway, were enriched in the high-GJA1-expression group.
Immune cell abundance analysis revealed that the abundance of CD8 naive, DC, and neutrophil was significantly increased in the high-GJA1-expression group.
In conclusion, GJA1 can be regarded as a potential prognostic marker of poor survival and therapeutic target in CC.
Moreover, many cancer-related pathways may be the critical pathways regulated by GJA1.
Furthermore, GJA1 can affect the abundance of immune cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meng, Silu& Fan, Xinran& Zhang, Jianwei& An, Ran& Li, Shuang. 2020. GJA1 Expression and Its Prognostic Value in Cervical Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1137710
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meng, Silu…[et al.]. GJA1 Expression and Its Prognostic Value in Cervical Cancer. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1137710
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meng, Silu& Fan, Xinran& Zhang, Jianwei& An, Ran& Li, Shuang. GJA1 Expression and Its Prognostic Value in Cervical Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1137710
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137710
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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