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Pharmacological Properties of a Traditional Korean Formula Bojungchiseup-tang on 3T3-L1 Preadipocytes and High-Fat Diet-Induced Obesity Mouse Model
المؤلفون المشاركون
Lee, Dong-Sung
Park, Yea-Jin
Seo, Dong-Wook
Gil, Tae-Young
Cominguez, Divina C.
Lee, Hwan
Han, Insik
An, Hyo-Jin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-29
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The global obesity epidemic has nearly doubled since 1980, and this increasing prevalence is threatening public health.
It has been reported that natural products could contain potential functional ingredients that may assist in preventing obesity.
Bojungchiseub-tang (BJT), mentioned in the Donguibogam as an herbal medication for the treatment of edema, a symptom of obesity, consists of eleven medicinal herbs.
However, the pharmacological activity of BJT has not been investigated.
The present study was designed to investigate the putative effect of BJT on the adipogenesis of 3T3-L1 cells and the weight gain of high-fat diet (HFD-) fed C57BL/6 mice.
Oil Red O staining was conducted to examine the amount of lipids in 3T3-L1 adipocytes.
Male C57BL/6 mice were divided into three groups: standard diet group (control, CON), 45% HFD group (HFD), and HFD supplemented with 10% of BJT (BJT).
The expression levels of genes and proteins related to adipogenesis in cells, WAT, and liver were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot, respectively.
We found that BJT treatment significantly decreased the protein and mRNA levels of peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer-binding protein α (C/EBPα), and sterol regulatory element-binding protein 1 (SREBP1) in a dose-dependent manner in differentiated 3T3-L1 cells.
Similar to the results of the in vitro experiment, BJT suppressed HFD-induced weight gain in an obese mouse model.
In addition, BJT effectively reduced the HFD-induced epididymal adipose tissue weight/body weight index.
BJT also downregulated the mRNA levels of PPARγ, C/EBPα, and SREBP1 in the epididymal adipose and liver tissue of HFD-fed obese mice.
These findings suggest that BJT induces weight loss by affecting adipogenic transcription factors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Yea-Jin& Seo, Dong-Wook& Gil, Tae-Young& Cominguez, Divina C.& Lee, Hwan& Lee, Dong-Sung…[et al.]. 2020. Pharmacological Properties of a Traditional Korean Formula Bojungchiseup-tang on 3T3-L1 Preadipocytes and High-Fat Diet-Induced Obesity Mouse Model. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137757
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Yea-Jin…[et al.]. Pharmacological Properties of a Traditional Korean Formula Bojungchiseup-tang on 3T3-L1 Preadipocytes and High-Fat Diet-Induced Obesity Mouse Model. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1137757
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Yea-Jin& Seo, Dong-Wook& Gil, Tae-Young& Cominguez, Divina C.& Lee, Hwan& Lee, Dong-Sung…[et al.]. Pharmacological Properties of a Traditional Korean Formula Bojungchiseup-tang on 3T3-L1 Preadipocytes and High-Fat Diet-Induced Obesity Mouse Model. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1137757
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137757
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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