Effect of a Carbohydrate-Rich Diet on Rat Detrusor Smooth Muscle Contractility: An Experimental Study

الملخص EN

Objectives.

We aimed to investigate the effect of a carbohydrate-rich diet on detrusor contractility in rats.

Materials and Methods.

Sprague-Dawley rats were randomized into two groups.

The control group received regular food and water.

The study group received carbohydrate-rich diet for six weeks.

The rats’ detrusor muscle was isolated for pharmacological and histopathological examinations.

Results.

In the control and study groups, mean body weights were 431.5 ± 27.6 g and 528.0 ± 36.2 g, respectively (p < 0.001).

Electrical stimulation of the detrusor strips of the control group resulted in gradual contraction.

A decreased contractile response was shown in the study group.

Acetylcholine in 10-7-10-3 molar concentration produced a decreased contractile response in the study group, compared to the control group (p < 0.01).

The study group showed marked subepithelial and intermuscular fibrosis in the bladder.

Conclusion.

Carbohydrate-rich diet causes marked subepithelial and extracellular fibrosis and changes in contractility in the detrusor within a six-week period.

Changes have higher costs in therapeutic choices and correction of these changes remains difficult.

Putting an end to carbohydrate-rich diet would seem to be more cost-effective than dealing with the effects of consuming it in high proportions which should be the national policy worldwide.