Efficacy and Mechanism of Preoperative Simvastatin Therapy on Myocardial Protection after Extracorporeal Circulation
المؤلفون المشاركون
Hua, Ping
Liu, Jian-Yang
Tao, Jun
Lin, Xifeng
Zou, Rongjun
Yang, Songran
Zhang, Dingwen
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Cardiopulmonary bypass (CPB) causes systemic inflammatory response and ischemia-reperfusion (IR) injury.
Objective.
To investigate the effect and mechanism of simvastatin on myocardial injury in cardiac valve surgery with CPB.
Methods.
One hundred thirty patients were randomly assigned to the statin group (n=65) or control group (n=65).
Simvastatin was administered preoperatively and postoperatively.
Duration of intensive care unit stay, duration of assisted ventilation, and left ventricular ejection fraction were recorded.
Plasma was analysed for troponin T (cTnT), isoenzyme of creatine kinase (CK-MB), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8).
Ultrastructure of the myocardium and autophagosomes were observed.
Beclin-1, LC3-II/I, P62, AMPK, and the phosphorylation of AMPK in cardiomyocytes were detected.
Results.
Simvastatin significantly reduced the duration of assisted ventilation (P=0.030) and ejection fraction was significantly higher in the statin group (P=0.024).
Simvastatin significantly reduced the levels of cTnT, CK-MB, TNF-α, IL-6, and IL-8 (P<0.05), reduced the expression of LC3-II/LC3-I and Beclin 1, and increased the expression of phosphorylation of AMPK.
Simvastatin reduced the generation of autophagosomes and the ultrastructural injuries to myocardium.
Conclusion.
Perioperative statin therapy reduced myocardial injury by regulating myocardial autophagy and activating the phosphorylation of AMPK.
The registration number of this study is ChiCTR-TRC-14005164.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hua, Ping& Liu, Jian-Yang& Tao, Jun& Zou, Rongjun& Lin, Xifeng& Zhang, Dingwen…[et al.]. 2017. Efficacy and Mechanism of Preoperative Simvastatin Therapy on Myocardial Protection after Extracorporeal Circulation. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137934
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hua, Ping…[et al.]. Efficacy and Mechanism of Preoperative Simvastatin Therapy on Myocardial Protection after Extracorporeal Circulation. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1137934
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hua, Ping& Liu, Jian-Yang& Tao, Jun& Zou, Rongjun& Lin, Xifeng& Zhang, Dingwen…[et al.]. Efficacy and Mechanism of Preoperative Simvastatin Therapy on Myocardial Protection after Extracorporeal Circulation. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137934
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137934
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر