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Limb Ischemic Postconditioning Alleviates Postcardiac Arrest Syndrome through the Inhibition of Mitochondrial Permeability Transition Pore Opening in a Porcine Model
المؤلفون المشاركون
Xu, Jiefeng
Ye, Sen
Li, Zilong
Wang, Zhengquan
Wu, Lifeng
Gao, Jindan
Chen, Yuanzhuo
Zhang, Xiangyu
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
Previously, the opening of mitochondrial permeability transition pore (mPTP) was confirmed to play a key role in the pathophysiology of postcardiac arrest syndrome (PCAS).
Recently, we demonstrated that limb ischemic postconditioning (LIpostC) alleviated cardiac and cerebral injuries after cardiac arrest and resuscitation.
In this study, we investigated whether LIpostC would alleviate the severity of PCAS through inhibiting mPTP opening.
Methods.
Twenty-four male domestic pigs weighing 37±2 kg were randomly divided into three groups: control, LIpostC, and LIpostC+atractyloside (Atr, the mPTP opener).
Atr (10 mg/kg) was intravenously injected 30 mins prior to the induction of cardiac arrest.
The animals were subjected to 10 mins of untreated ventricular fibrillation and 5 mins of cardiopulmonary resuscitation.
Coincident with the beginning of cardiopulmonary resuscitation, LIpostC was induced by four cycles of 5 mins of limb ischemia and then 5 mins of reperfusion.
The resuscitated animals were monitored for 4 hrs and observed for an additional 68 hrs.
Results.
After resuscitation, systemic inflammation and multiple organ injuries were observed in all resuscitated animals.
However, postresuscitation systemic inflammation was significantly milder in the LIpostC group than in the control group.
Myocardial, lung, and brain injuries after resuscitation were significantly improved in the LIpostC group compared to the control group.
Nevertheless, pretreatment with Atr abolished all the protective effects induced by LIpostC.
Conclusion.
LIpostC significantly alleviated the severity of PCAS, in which the protective mechanism was associated with the inhibition of mPTP opening.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Zhengquan& Wu, Lifeng& Xu, Jiefeng& Gao, Jindan& Ye, Sen& Li, Zilong…[et al.]. 2020. Limb Ischemic Postconditioning Alleviates Postcardiac Arrest Syndrome through the Inhibition of Mitochondrial Permeability Transition Pore Opening in a Porcine Model. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1137985
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Zhengquan…[et al.]. Limb Ischemic Postconditioning Alleviates Postcardiac Arrest Syndrome through the Inhibition of Mitochondrial Permeability Transition Pore Opening in a Porcine Model. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1137985
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Zhengquan& Wu, Lifeng& Xu, Jiefeng& Gao, Jindan& Ye, Sen& Li, Zilong…[et al.]. Limb Ischemic Postconditioning Alleviates Postcardiac Arrest Syndrome through the Inhibition of Mitochondrial Permeability Transition Pore Opening in a Porcine Model. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1137985
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137985
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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