Caspase-1-Dependent Pyroptosis of Peripheral Blood Mononuclear Cells Is Associated with the Severity and Mortality of Septic Patients

المؤلفون المشاركون

Wang, Yuchang
Liu, Yukun
Liu, Qinxin
Zheng, Qiang
Dong, Xijie
Liu, Xinghua
Gao, Wei
Bai, Xiangjun
Li, Zhanfei

المصدر

BioMed Research International

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-02-29

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

Purpose.

Pyroptosis has been known to play a vital role in the inflammation process which was induced by infection, injury, or inflammatory disease.

The present study was aimed at evaluating the percentage of peripheral blood mononuclear cell (PBMC) pyroptosis in septic patients and assessing the correlation of PBMC pyroptosis with the severity and the mortality of septic patients.

Methods.

128 trauma-induced patients with sepsis were enrolled in this prospective cohort study.

Blood samples were collected, and PBMC pyroptosis was measured by flow cytometry within 24 hours after sepsis was diagnosed.

Results.

Percentage of PBMC pyroptosis was positively correlated with the acute physiology and chronic health evaluation (APACHE) II score and sequential organ failure assessment (SOFA) score (all P<0.01).

The area under the curve (AUC) for the percentage of PBMC pyroptosis on a receiver operating characteristic curve was 0.79 (95% confidence interval (CI), 0.68–0.90).

A Cox proportional hazard model identified an association between an increased percentage of PBMC pyroptosis (>14.17%) and increased risk of the 28-day mortality (hazard ratio=1.234, 95% CI, 1.014–1.502).

Conclusion.

The percentage of PBMC pyroptosis increases in septic patients, and the increased percentage of PBMC pyroptosis is associated with the severity of sepsis and the 28-day mortality of patients with sepsis.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wang, Yuchang& Liu, Yukun& Liu, Qinxin& Zheng, Qiang& Dong, Xijie& Liu, Xinghua…[et al.]. 2020. Caspase-1-Dependent Pyroptosis of Peripheral Blood Mononuclear Cells Is Associated with the Severity and Mortality of Septic Patients. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137990

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wang, Yuchang…[et al.]. Caspase-1-Dependent Pyroptosis of Peripheral Blood Mononuclear Cells Is Associated with the Severity and Mortality of Septic Patients. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1137990

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wang, Yuchang& Liu, Yukun& Liu, Qinxin& Zheng, Qiang& Dong, Xijie& Liu, Xinghua…[et al.]. Caspase-1-Dependent Pyroptosis of Peripheral Blood Mononuclear Cells Is Associated with the Severity and Mortality of Septic Patients. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137990

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1137990