Outcomes of Hypofractional Tomotherapy in Patients with Stage III Nonsmall Cell Lung Cancer Who Are Not Eligible for Surgery or Concurrent Chemoradiation
المؤلفون المشاركون
Ren, Gang
Li, Jing
Li, Hongqi
Wang, Yingjie
Liu, Junyang
Wang, Xuan
Pang, Haifeng
Chang, Dongshu
Di, Yupeng
Li, Ping
Wang, Yong
Liu, Chen
Chen, Xiao
Kang, Xiaoli
Xia, Tingyi
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
We assessed the clinical outcomes and toxicities following hypofractionation with helical tomographic intensity-modulated radiotherapy technology (tomotherapy) in patients with stage III non-small cell lung cancer (NSCLC) who were not candidates for surgery or concurrent chemoradiation.
Methods.
Forty-three patients with stage III NSCLC who were treated between 2011 and 2017 were enrolled.
The prescription doses for gross target volume and clinical target volume were 70 Gy and 60 Gy (respectively) delivered in 15–25 fractions over 3–5 weeks.
Results.
The median overall survival (OS) time was 34.23 (range 11.33–99.33) months.
The estimated 1-, 2-, and 3-year OS rates were 97.7%, 74.4%, and 55.9%, respectively; the corresponding progression-free survival (PFS) rates were 79.1%, 53.5%, and 36.1%, respectively.
The local disease recurrence, regional disease recurrence, and distant metastasis rates at 3 years were 4.7%, 11.62%, and 55.81%, respectively.
On multivariate analysis, dose regimen (<19 f vs.
≥19 f) was an independent prognostic factor affecting OS, PFS, and DM (p<0.05).
Seven patients developed grade 1-2 acute radiation pneumonia (RP), 5 patients developed grade 1-2 late RP, while 3 patients developed grade 3 late RP.
None of the patients developed grade 4-5 radiation lung injury.
Conclusion.
Tomotherapy may be an effective treatment option for patients with stage III NSCLC.
It may be a viable alternative to surgery with lower incidence of side effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jing& Li, Hongqi& Wang, Yingjie& Liu, Junyang& Wang, Xuan& Pang, Haifeng…[et al.]. 2020. Outcomes of Hypofractional Tomotherapy in Patients with Stage III Nonsmall Cell Lung Cancer Who Are Not Eligible for Surgery or Concurrent Chemoradiation. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137999
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jing…[et al.]. Outcomes of Hypofractional Tomotherapy in Patients with Stage III Nonsmall Cell Lung Cancer Who Are Not Eligible for Surgery or Concurrent Chemoradiation. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1137999
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jing& Li, Hongqi& Wang, Yingjie& Liu, Junyang& Wang, Xuan& Pang, Haifeng…[et al.]. Outcomes of Hypofractional Tomotherapy in Patients with Stage III Nonsmall Cell Lung Cancer Who Are Not Eligible for Surgery or Concurrent Chemoradiation. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137999
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1137999
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر