HPV Status and Its Correlation with BCL2, p21, p53, Rb, and Survivin Expression in Breast Cancer in a Chinese Population
المؤلفون المشاركون
Wang, Ya-Wen
Zhang, Kai
Zhao, Song
Lv, Yanrong
Zhu, Jiang
Liu, Huantao
Feng, Jinbo
Liang, Weili
Ma, Rong
Wang, Jianli
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-20
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Despite recent evidence, the role of human papillomavirus (HPV) in breast carcinogenesis is controversial.
The correlations of HPV infection with the clinicopathological features of breast cancer and the expression of cell cycle/apoptosis-associated proteins have not been well elucidated.
In this study, we sought to determine the prevalence of high-risk HPVs (HR-HPVs) infection and BCL2, p21, p53, Rb, and survivin expression in breast cancer patients and to investigate the relationship of HPV with these cancer-related proteins, in an attempt to clarify the potential mechanism of HPV in breast cancer pathogenesis.
HPV presence in 81 fresh breast cancer tissues was determined by hybrid capture 2 (HC2) assay, and expression of BCL2, p21, p53, Rb, and survivin was detected by immunohistochemistry.
Here we showed that fourteen (17.3%) patients were HR-HPV positive.
HPV infection demonstrated no significant correlation with the clinicopathological characteristics of breast cancer.
HPV-positive tumors showed significantly higher BCL2 and lower p53 expression than HPV-negative tumors.
Expression of p21, Rb, and survivin was not associated with HPV status.
Our results suggest a possible role of HR-HPV in breast cancer carcinogenesis, in which BCL2 and p53 may be involved.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Ya-Wen& Zhang, Kai& Zhao, Song& Lv, Yanrong& Zhu, Jiang& Liu, Huantao…[et al.]. 2017. HPV Status and Its Correlation with BCL2, p21, p53, Rb, and Survivin Expression in Breast Cancer in a Chinese Population. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138037
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Ya-Wen…[et al.]. HPV Status and Its Correlation with BCL2, p21, p53, Rb, and Survivin Expression in Breast Cancer in a Chinese Population. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138037
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Ya-Wen& Zhang, Kai& Zhao, Song& Lv, Yanrong& Zhu, Jiang& Liu, Huantao…[et al.]. HPV Status and Its Correlation with BCL2, p21, p53, Rb, and Survivin Expression in Breast Cancer in a Chinese Population. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138037
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138037
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر