Nonuniform Internal Structure of Fibrin Fibers: Protein Density and Bond Density Strongly Decrease with Increasing Diameter
المؤلفون المشاركون
Pieters, Marlien
Li, Wei
Sigley, Justin
Baker, Stephen R.
Helms, Christine C.
Kinney, Mary T.
Brubaker, Peter H.
Cubcciotti, Roger
Guthold, Martin
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-10
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The major structural component of a blood clot is a meshwork of fibrin fibers.
It has long been thought that the internal structure of fibrin fibers is homogeneous; that is, the protein density and the bond density between protofibrils are uniform and do not depend on fiber diameter.
We performed experiments to investigate the internal structure of fibrin fibers.
We formed fibrin fibers with fluorescently labeled fibrinogen and determined the light intensity of a fiber, I, as a function of fiber diameter, D.
The intensity and, thus, the total number of fibrin molecules in a cross-section scaled as D1.4.
This means that the protein density (fibrin per cross-sectional area), ρp, is not homogeneous but instead strongly decreases with fiber diameter as D-0.6.
Thinner fibers are denser than thicker fibers.
We also determined Young’s modulus, Y, as a function of fiber diameter.
Y decreased strongly with increasing D; Y scaled as D-1.5.
This implies that the bond density, ρb, also scales as D-1.5.
Thinner fibers are stiffer than thicker fibers.
Our data suggest that fibrin fibers have a dense, well-connected core and a sparse, loosely connected periphery.
In contrast, electrospun fibrinogen fibers, used as a control, have a homogeneous cross-section.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Wei& Sigley, Justin& Baker, Stephen R.& Helms, Christine C.& Kinney, Mary T.& Pieters, Marlien…[et al.]. 2017. Nonuniform Internal Structure of Fibrin Fibers: Protein Density and Bond Density Strongly Decrease with Increasing Diameter. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1138076
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Wei…[et al.]. Nonuniform Internal Structure of Fibrin Fibers: Protein Density and Bond Density Strongly Decrease with Increasing Diameter. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1138076
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Wei& Sigley, Justin& Baker, Stephen R.& Helms, Christine C.& Kinney, Mary T.& Pieters, Marlien…[et al.]. Nonuniform Internal Structure of Fibrin Fibers: Protein Density and Bond Density Strongly Decrease with Increasing Diameter. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1138076
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138076
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر