Electroacupuncture Prevents Osteoarthritis of High-Fat Diet-Induced Obese Rats
المؤلفون المشاركون
Pang, Xianlun
Xie, Lin-Lin
Zhao, Yu-Li
Yang, Jian
Cheng, Hui
Zhong, Zhen-Dong
Liu, Yi-Ru
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-08
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
The effects of acupuncture on osteoarthritis (OA) pathogenesis have been demonstrated in vitro and in animal models.
However, the potential for acupuncture to mediate protective effects on obese-induced OA has not been examined.
Here, we investigated the effects of different acupuncture patterns on OA pathogenesis in high-fat diet- (HFD-) induced obese rats.
After 12-week diet-induced obesity, obese rats were treated with three acupuncture protocols for 2 weeks, including ST36, GB34, and ST36+GB34.
The results showed that the three acupuncture protocols both prevented obesity-induced cartilage matrix degradation and MMP expression and mitigated obesity-induced systemic and local inflammation but had different regulatory effects on lipid metabolism and gut microbiota disorder of obese-induced OA rats.
Furthermore, the three acupuncture protocols increased the microbial diversity and altered the structure of community of feces in obese rats.
We found that ST36 and GB34 could inhibit proinflammatory shift in the gut microbiome with an increase in the ratio of Bacteroidetes/Firmicutes and promote the recovery of relative abundance of Clostridium, Akkermansia, Butyricimonas, and Lactococcus.
Although both ST36 and GB34 had an anti-inflammatory effect on serum inflammatory mediators, only the acupuncture protocol with both ST36 and GB34 could effectively inhibit LPS-mediated joint inflammation in obesity rats.
Therefore, relieving obesity-related chronic inflammation, lipid metabolism disorder, and gut microbiota disorder may be an important mechanism for acupuncture with ST36 and GB34 to promote OA recovery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xie, Lin-Lin& Zhao, Yu-Li& Yang, Jian& Cheng, Hui& Zhong, Zhen-Dong& Liu, Yi-Ru…[et al.]. 2020. Electroacupuncture Prevents Osteoarthritis of High-Fat Diet-Induced Obese Rats. BioMed Research International،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1138094
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xie, Lin-Lin…[et al.]. Electroacupuncture Prevents Osteoarthritis of High-Fat Diet-Induced Obese Rats. BioMed Research International No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1138094
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xie, Lin-Lin& Zhao, Yu-Li& Yang, Jian& Cheng, Hui& Zhong, Zhen-Dong& Liu, Yi-Ru…[et al.]. Electroacupuncture Prevents Osteoarthritis of High-Fat Diet-Induced Obese Rats. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1138094
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138094
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر