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Evaluation of Plasma MicroRNAs as Diagnostic and Prognostic Biomarkers in Pancreatic Adenocarcinoma: miR-196a and miR-210 Could Be Negative and Positive Prognostic Markers, Respectively
المؤلفون المشاركون
Yu, Qi
Xu, Changqing
Yuan, Wei
Zhao, Ping
Chen, Lianzhen
Ma, Jie
Wang, Chengfeng
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-29
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Identifying diagnostic and prognostic biomarkers that could be targeted in the therapy of pancreatic cancer is essential.
Objective.
Investigations were conducted with respect to plasma miRNA (miR-21, miR-210, miR-155, miR-196a, miR-20a, and miR-25) expression and clinicopathologic factors to evaluate the prognostic value of miRNAs in pancreatic ductal adenocarcinoma (PDAC).
Methods.
Plasma miRNAs were detected by real-time quantitative PCR, and the association with clinicopathologic factors was subsequently performed by univariate and multivariate analyses.
Results.
Six miRNAs expressed significantly higher in PDAC patients than in normal individuals were identified.
Receiver operating characteristic (ROC) curves were constructed.
It was evident that miRNA expression associated with PDAC, lymph node metastasis, serosal infiltration, and comprehensive therapy reached significance for overall survival.
High miR-196a expression was associated with poor survival (P=0.001), whereas high miR-210 expression was significantly associated with improved survival (P=0.003).
Multivariate survival analysis indicated that the miR-210 and miR-196a expression signature, lymph node metastasis, and comprehensive therapy were independent factors affecting overall survival.
Conclusions.
MiRNA expression profile is distinctive in PDAC.
Aberrant expression of certain miRNAs was remarkably involved in shaping the overall survival time, which include miR-196a overexpression and decreased miR-210 expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Qi& Xu, Changqing& Yuan, Wei& Wang, Chengfeng& Zhao, Ping& Chen, Lianzhen…[et al.]. 2017. Evaluation of Plasma MicroRNAs as Diagnostic and Prognostic Biomarkers in Pancreatic Adenocarcinoma: miR-196a and miR-210 Could Be Negative and Positive Prognostic Markers, Respectively. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138118
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Qi…[et al.]. Evaluation of Plasma MicroRNAs as Diagnostic and Prognostic Biomarkers in Pancreatic Adenocarcinoma: miR-196a and miR-210 Could Be Negative and Positive Prognostic Markers, Respectively. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1138118
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Qi& Xu, Changqing& Yuan, Wei& Wang, Chengfeng& Zhao, Ping& Chen, Lianzhen…[et al.]. Evaluation of Plasma MicroRNAs as Diagnostic and Prognostic Biomarkers in Pancreatic Adenocarcinoma: miR-196a and miR-210 Could Be Negative and Positive Prognostic Markers, Respectively. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138118
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138118
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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