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TRPM7 Upregulate the Activity of SMAD1 through PLC Signaling Way to Promote Osteogenesis of hBMSCs
المؤلفون المشاركون
Fu, Yong
Zhang, Cui
Chen, Jianling
Wang, Jinfu
Hong, Fanfan
Wu, Shali
Li, Liang
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-23، 23ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-27
دولة النشر
مصر
عدد الصفحات
23
التخصصات الرئيسية
الملخص EN
TRPM7 is a member of the transient receptor potential cation channel (TRP channel) subfamily M and possesses both an ion channel domain and a functional serine/threonine α-kinase domain.
It has been proven to play an essential role in the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs).
However, the signaling pathway and molecular mechanism for TRPM7 in regulating osteogenic differentiation remain largely unknown.
In this study, the potential role and mechanism of TRPM7 in the osteogenic differentiation of hBMSCs were investigated.
The results showed that the expression of TRPM7 mRNA and protein increased, as did the osteogenic induction time.
Upregulation or inhibition of TRPM7 could promote or inhibit the osteogenic differentiation of hBMSCs for 14 days.
It was also found that the upregulation or inhibition of TRPM7 promoted or inhibited the activity of PLC and SMAD1, respectively, during osteogenic differentiation.
PLC could promote osteogenic differentiation by upregulating the activity of SMAD1.
However, inhibition of PLC alone could reduce the activity of SMAD1 but not inhibit completely the activation of SMAD1.
Therefore, we inferred that it is an important signaling pathway for TRPM7 to upregulate the activity of SMAD1 through PLC and thereby promote the osteogenic differentiation of hBMSCs, but it is not a singular pathway.
TRPM7 may also regulate the activation of SMAD1 through other ways, except for PLC, during osteogenic differentiation of hBMSCs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hong, Fanfan& Wu, Shali& Zhang, Cui& Li, Liang& Chen, Jianling& Fu, Yong…[et al.]. 2020. TRPM7 Upregulate the Activity of SMAD1 through PLC Signaling Way to Promote Osteogenesis of hBMSCs. BioMed Research International،Vol. 2020, no. 2020, pp.1-23.
https://search.emarefa.net/detail/BIM-1138119
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hong, Fanfan…[et al.]. TRPM7 Upregulate the Activity of SMAD1 through PLC Signaling Way to Promote Osteogenesis of hBMSCs. BioMed Research International No. 2020 (2020), pp.1-23.
https://search.emarefa.net/detail/BIM-1138119
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hong, Fanfan& Wu, Shali& Zhang, Cui& Li, Liang& Chen, Jianling& Fu, Yong…[et al.]. TRPM7 Upregulate the Activity of SMAD1 through PLC Signaling Way to Promote Osteogenesis of hBMSCs. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-23.
https://search.emarefa.net/detail/BIM-1138119
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138119
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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