Quercetin Downregulates Cyclooxygenase-2 Expression and HIF-1αVEGF Signaling-Related Angiogenesis in a Mouse Model of Abdominal Aortic Aneurysm
المؤلفون المشاركون
Zhu, Xian
Wang, Lian
Wu, Haiwei
Xiong, Lei
Liu, Xiaolong
Yang, Nan
Luo, Liguo
Qin, Tao
Shen, Zhonghua
Jing, Hua
Chen, Jinming
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-24
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
Abdominal aortic aneurysm (AAA) development has been characterized by increased expression of vascular endothelial growth factor (VEGF), which contributes to angiogenesis via cyclooxygenase-2 (COX-2).
Quercetin, one of the most common and well-researched flavonoids and abundant in vegetables and fruits, has beneficial effects in inhibiting angiogenesis.
This study investigated the antiangiogenic effects of quercetin on experimental aneurysms.
Methods.
We utilized the in vivo AAA mouse model induced by the periaortic application of CaCl2 to examine the effectiveness of quercetin in blocking angiogenesis.
Quercetin was administered at 60 mg/kg once daily on the day of the AAA induction and then continued for 6 weeks.
Celecoxib, a selective COX-2 inhibitor, was used as the positive control.
Results.
Our results demonstrated that quercetin significantly attenuated aneurysm growth in AAA mice and medial neovascularization.
Accordingly, quercetin decreased the expression of proangiogenic mediators, including VEGF-A, intercellular adhesion molecule-1, vascular cell adhesion molecule 1, and vascular endothelial cadherin.
Quercetin treatment also inhibited the expression of COX-2 and hypoxia-inducible factor 1α (HIF-1α).
It was also found that quercetin-3-glucuronide, a major quercetin metabolite, downregulated the expression of COX-2, HIF-1α, VEGF-A, and matrix metalloproteinase activities in aortic vascular smooth muscle cells isolated from AAA mice.
Conclusion.
Quercetin attenuates neovascularization during AAA growth, and this effect is mediated via the inhibition of COX-2, which decreases HIF-1α/VEGF signaling-related angiogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Lian& Wu, Haiwei& Xiong, Lei& Liu, Xiaolong& Yang, Nan& Luo, Liguo…[et al.]. 2020. Quercetin Downregulates Cyclooxygenase-2 Expression and HIF-1αVEGF Signaling-Related Angiogenesis in a Mouse Model of Abdominal Aortic Aneurysm. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1138132
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Lian…[et al.]. Quercetin Downregulates Cyclooxygenase-2 Expression and HIF-1αVEGF Signaling-Related Angiogenesis in a Mouse Model of Abdominal Aortic Aneurysm. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1138132
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Lian& Wu, Haiwei& Xiong, Lei& Liu, Xiaolong& Yang, Nan& Luo, Liguo…[et al.]. Quercetin Downregulates Cyclooxygenase-2 Expression and HIF-1αVEGF Signaling-Related Angiogenesis in a Mouse Model of Abdominal Aortic Aneurysm. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1138132
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138132
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر