Hypofibrinolytic State in Subjects with Type 2 Diabetes Mellitus Aggravated by the Metabolic Syndrome before Clinical Manifestations of Atherothrombotic Disease
المؤلفون المشاركون
Leaños-Miranda, Alfredo
Isordia-Salas, Irma
Santiago-Germán, David
López-Alarcón, Mardia
Aburto-Mejía, Elsa
Martínez-Marino, Manuel
María Eugenia Galván-Plata, Manuel
Almeida-Gutiérrez, Eduardo
Hernández-Juárez, Jesús
Majluf-Cruz, Abraham
Alvarado-Moreno, Antonio
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Metabolic and genetic factors induce plasminogen activator inhibitor type-1 (PAI-1) overexpression; higher PAI-1 levels decrease fibrinolysis and promote atherothrombosis.
Aim.
To assess PAI-1 antigen levels among subjects with type 2 diabetes mellitus (T2DM) plus Metabolic Syndrome (MetS) before clinical manifestations of atherothrombosis and the contribution of metabolic factors and 4G/5G polymorphism of PAI-1 gene on the variability of PAI-1.
Methods.
We conducted an observational, cross-sectional assay in a hospital in Mexico City from May 2010 to September 2011.
MetS was defined by the International Diabetes Federation criteria.
PAI-1 levels and 4G/5G polymorphism were determined by ELISA and PCR-RFLP analysis.
Results.
We enrolled 215 subjects with T2DM plus MetS and 307 controls.
Subjects with T2DM plus MetS had higher PAI-1 levels than the reference group (58.4 ± 21 versus 49.9 ± 16 ng/mL, p=0.026).
A model with components of MetS explained only 12% of variability on PAI-1 levels (R2 = 0.12; p=0.001), with β=0.18 (p=0.03) for hypertension, β=-0.16 (p=0.05) for NL HDL-c, and β=0.15 (p=0.05) for NL triglycerides.
Conclusion.
Subjects with T2DM plus MetS have elevated PAI-1 levels before clinical manifestations of atherothrombotic disease.
Metabolic factors have a more important contribution than 4G/5G polymorphism on PAI-1 plasma variability.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aburto-Mejía, Elsa& Santiago-Germán, David& Martínez-Marino, Manuel& María Eugenia Galván-Plata, Manuel& Almeida-Gutiérrez, Eduardo& López-Alarcón, Mardia…[et al.]. 2017. Hypofibrinolytic State in Subjects with Type 2 Diabetes Mellitus Aggravated by the Metabolic Syndrome before Clinical Manifestations of Atherothrombotic Disease. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138136
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aburto-Mejía, Elsa…[et al.]. Hypofibrinolytic State in Subjects with Type 2 Diabetes Mellitus Aggravated by the Metabolic Syndrome before Clinical Manifestations of Atherothrombotic Disease. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1138136
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aburto-Mejía, Elsa& Santiago-Germán, David& Martínez-Marino, Manuel& María Eugenia Galván-Plata, Manuel& Almeida-Gutiérrez, Eduardo& López-Alarcón, Mardia…[et al.]. Hypofibrinolytic State in Subjects with Type 2 Diabetes Mellitus Aggravated by the Metabolic Syndrome before Clinical Manifestations of Atherothrombotic Disease. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1138136
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138136
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر