Increased Expression of TIGITCD57 in Peripheral BloodBone Marrow NK Cells in Patients with Chronic Myeloid Leukemia
المؤلفون المشاركون
Lai, Jing
Xu, Ling
Jin, Zhenyi
Chen, Shaohua
Zha, Xianfeng
Yao, Danlin
Liu, Lian
Zeng, Xiangbo
Zhong, Juan
Zheng, Runhui
Huang, Xin
Lu, Yuhong
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The antitumor activity of NK cells in patients with chronic myeloid leukemia (CML) is inhibited by the leukemia microenvironment.
Recent studies have identified that the expression of TIGIT, CD57, and KLRG1 is related to the function, maturation, and antitumor capabilities of NK cells.
However, the characteristics of the expression of these genes in the peripheral blood (PB) and bone marrow (BM) from patients with CML remain unknown.
In this study, we used multicolor flow cytometry to assay the quantity and phenotypic changes of NK cells in PB and BM from de novo CML (DN-CML) and CML patients acquiring molecular response (MR-CML).
We found that the expression of TIGIT, which inhibits NK cell function, is increased on CD56+ and CD56dim NK cells in DN-CML PB compared with those in healthy individuals (HIs), and it is restored to normal in patients who achieve MR.
We also found that the expression of CD57 on NK cells was approximately the same level in PB and BM from DN-CML patients, while decreased CD57 expression was found on CD56+ and CD56dim NK cells in HI BM compared with PB.
Additionally, those two subsets were significantly increased in DN-CML BM compared to HI BM.
The expression of CD57 correlates with replicative senescence and maturity for human NK cells; therefore, the increase in TIGIT on PB NK cells together with an increase in CD57 on BM NK cells may explain the subdued NK cell antileukemia capacity and proliferative ability in DN-CML patients.
These results indicate that reversing the immune suppression of PB NK cells by blocking TIGIT while improving the proliferation of BM NK cells via targeting CD57 may be more effective in removing tumor cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yao, Danlin& Xu, Ling& Liu, Lian& Zeng, Xiangbo& Zhong, Juan& Lai, Jing…[et al.]. 2020. Increased Expression of TIGITCD57 in Peripheral BloodBone Marrow NK Cells in Patients with Chronic Myeloid Leukemia. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1138163
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yao, Danlin…[et al.]. Increased Expression of TIGITCD57 in Peripheral BloodBone Marrow NK Cells in Patients with Chronic Myeloid Leukemia. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1138163
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yao, Danlin& Xu, Ling& Liu, Lian& Zeng, Xiangbo& Zhong, Juan& Lai, Jing…[et al.]. Increased Expression of TIGITCD57 in Peripheral BloodBone Marrow NK Cells in Patients with Chronic Myeloid Leukemia. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1138163
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138163
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر