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lncRNA MRUL Suppressed Non-Small Cell Lung Cancer Cells Proliferation and Invasion by Targeting miR-17-5pSRSF2 Axis
المؤلفون المشاركون
Ma, Cui
Shen, Tianle
Ding, Xuping
Sheng, Liming
Du, Xianghui
Cheng, Lei
Chen, Ying
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-14
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The two broad histological subtypes of lung cancer are small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), which are the leading causes of cancer-related death in the world.
Long noncoding RNAs (lncRNAs) have been verified to be critical in the regulation of cancer development.
The present study identified and elucidated the regulatory roles of a novel lncRNA MRUL in NSCLC.
The results showed that MRUL was overexpressed in NSCLC samples and correlated with the poor prognosis of patients who had NSCLC.
Moreover, this research has for the first time demonstrated that MRUL acted as an oncogenetic lncRNA in NSCLC.
Knockdown of MRUL considerably repressed NSCLC cell proliferation, invasion, and migration.
The bioinformatics analysis showed that MRUL was involved in regulating multiple RNA splicing and proliferation-related biological processes, such as mRNA splicing, RNA splicing, mRNA processing, mRNA 3′-end processing, mRNA splice site selection, and DNA replication.
By combining bioinformatics analysis and experimental validation, we found that MRUL regulated NSCLC progression through promoting SRSF2 by sponging miR-17 in NSCLC cells.
The discoveries indicated that MRUL could be a therapeutic target and a potential diagnostic for NSCLC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Ying& Shen, Tianle& Ding, Xuping& Ma, Cui& Cheng, Lei& Sheng, Liming…[et al.]. 2020. lncRNA MRUL Suppressed Non-Small Cell Lung Cancer Cells Proliferation and Invasion by Targeting miR-17-5pSRSF2 Axis. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1138175
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Ying…[et al.]. lncRNA MRUL Suppressed Non-Small Cell Lung Cancer Cells Proliferation and Invasion by Targeting miR-17-5pSRSF2 Axis. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1138175
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Ying& Shen, Tianle& Ding, Xuping& Ma, Cui& Cheng, Lei& Sheng, Liming…[et al.]. lncRNA MRUL Suppressed Non-Small Cell Lung Cancer Cells Proliferation and Invasion by Targeting miR-17-5pSRSF2 Axis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1138175
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138175
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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