Abnormal Levels of Liver Enzymes and Hepatotoxicity in HIV-Positive, TB, and HIVTB-Coinfected Patients on Treatment in Fako Division, Southwest Region of Cameroon
المؤلفون المشاركون
Enoh, Jude Eteneneng
Cho, Frederick Nchang
Manfo, Faustin Pascal
Ako, Simon Eyongabane
Achidi, Eric A.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Hepatotoxicity is historically the 3rd most common reason for drug withdrawal and toxicity-related discontinuation of treatment.
This study was aimed at determining the incidence and the onset of hepatotoxicity and at evaluating the relationship of some risk factors for hepatotoxicity among Human Immunodeficiency Virus- (HIV-) positive, tuberculosis (TB), and HIV/TB patients on treatment.
This was a prospective follow-up study involving 125 participants from the HIV/AIDS and TB treatment centres in three hospitals in Fako Division of Cameroon.
These TB and HIV patients were initiated on RHEZ (R = Rifampicin, H = Isoniazid, E = Ethambutol, and P = Pyrazinamide) and TELE (efavirenz/tenofovir/lamivudine), respectively, and followed up for 12 weeks between September 2018 and November 2019.
The levels of liver enzymes (transaminases, gamma-glutamyltransferase, alkaline phosphatase, and unconjugated/total bilirubin) were measured spectrophotometrically using serum.
The Chi-squared (χ2) test was used to assess the association between risk factors and hepatotoxicity, while the Kaplan-Meier survival analysis with the log-rank test was used to determine the occurrence of hepatotoxicity in the different groups.
We followed the general study population for a total person time of 6580 person-days, with an incidence rate and cumulative incidence of 8 cases per 1000 person-days (53/6580 person-days) and 42.4% (53/125), respectively (95% confidence interval), recorded after 12 weeks of follow-up of all the participants.
The onset of hepatotoxicity in the total study population was statistically significant (χ2=9.5334; p=0.022979; CI=95%), with the majority observed at week eight of follow-up.
Also, the incidence rate and cumulative incidence of hepatotoxicity with respect to HIV/AIDS, TB, and HIV/TB patients, respectively, at 95% confidence interval were: 8 cases per 1000 person-days (32/3843 person-days) and 32/76 (42.1%), 6 cases per 1000 person-days (12/1932 person-days) and 12/32 (37.5%), and 11 cases per 1000 person-days (9/805 person-days) and 9/17 (52.9%).
This study shows that the incidence rate and cumulative incidence of hepatotoxicity in HIV/AIDS, TB, and HIV/TB patients on treatment were high in Fako Division, Cameroon.
Also, it is very important to check these patients’ liver function especially within the first 12 weeks of treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Enoh, Jude Eteneneng& Cho, Frederick Nchang& Manfo, Faustin Pascal& Ako, Simon Eyongabane& Achidi, Eric A.. 2020. Abnormal Levels of Liver Enzymes and Hepatotoxicity in HIV-Positive, TB, and HIVTB-Coinfected Patients on Treatment in Fako Division, Southwest Region of Cameroon. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138208
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Enoh, Jude Eteneneng…[et al.]. Abnormal Levels of Liver Enzymes and Hepatotoxicity in HIV-Positive, TB, and HIVTB-Coinfected Patients on Treatment in Fako Division, Southwest Region of Cameroon. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1138208
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Enoh, Jude Eteneneng& Cho, Frederick Nchang& Manfo, Faustin Pascal& Ako, Simon Eyongabane& Achidi, Eric A.. Abnormal Levels of Liver Enzymes and Hepatotoxicity in HIV-Positive, TB, and HIVTB-Coinfected Patients on Treatment in Fako Division, Southwest Region of Cameroon. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138208
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138208
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر