Development of Prognostic Indicator Based on Autophagy-Related lncRNA Analysis in Colon Adenocarcinoma
المؤلفون المشاركون
Chen, Zheng
Zhou, Weige
Zhang, Shijing
Li, Hui-biao
Cai, Zheyou
Tang, Shuting
Chen, Li-xia
Lang, Jian-ying
Chen, Xin-lin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-03
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
There were no systematic researches about autophagy-related long noncoding RNA (lncRNA) signatures to predict the survival of patients with colon adenocarcinoma.
It was necessary to set up corresponding autophagy-related lncRNA signatures.
The expression profiles of lncRNAs which contained 480 colon adenocarcinoma samples were obtained from The Cancer Genome Atlas (TCGA) database.
The coexpression network of lncRNAs and autophagy-related genes was utilized to select autophagy-related lncRNAs.
The lncRNAs were further screened using univariate Cox regression.
In addition, Lasso regression and multivariate Cox regression were used to develop an autophagy-related lncRNA signature.
A risk score based on the signature was established, and Cox regression was used to test whether it was an independent prognostic factor.
The functional enrichment of autophagy-related lncRNAs was visualized using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes.
Ten prognostic autophagy-related lncRNAs (AC027307.2, AC068580.3, AL138756.1, CD27-AS1, EIF3J-DT, LINC01011, LINC01063, LINC02381, AC073896.3, and SNHG16) were identified to be significantly different, which made up an autophagy-related lncRNA signature.
The signature divided patients with colon adenocarcinoma into the low-risk group and the high-risk group.
A risk score based on the signature was a significantly independent factor for the patients with colon adenocarcinoma (HR=1.088, 95%CI=1.057−1.120; P<0.001).
Additionally, the ten lncRNAs were significantly enriched in autophagy process, metabolism, and tumor classical pathways.
In conclusion, the ten autophagy-related lncRNAs and their signature might be molecular biomarkers and therapeutic targets for the patients with colon adenocarcinoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Weige& Zhang, Shijing& Li, Hui-biao& Cai, Zheyou& Tang, Shuting& Chen, Li-xia…[et al.]. 2020. Development of Prognostic Indicator Based on Autophagy-Related lncRNA Analysis in Colon Adenocarcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1138304
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Weige…[et al.]. Development of Prognostic Indicator Based on Autophagy-Related lncRNA Analysis in Colon Adenocarcinoma. BioMed Research International No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1138304
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Weige& Zhang, Shijing& Li, Hui-biao& Cai, Zheyou& Tang, Shuting& Chen, Li-xia…[et al.]. Development of Prognostic Indicator Based on Autophagy-Related lncRNA Analysis in Colon Adenocarcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1138304
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138304
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر