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Maternal Separation Early in Life Alters the Expression of Genes Npas4 and Nr1d1 in Adult Female Mice: Correlation with Social Behavior
المؤلفون المشاركون
Bondar, Natalya P.
Reshetnikov, Vasiliy V.
Ryabushkina, Yuliya A.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Early-life stress affects neuronal plasticity of the brain regions participating in the implementation of social behavior.
Our previous studies have shown that brief and prolonged separation of pups from their mothers leads to enhanced social behavior in adult female mice.
The goal of the present study was to characterize the expression of genes (which are engaged in synaptic plasticity) Egr1, Npas4, Arc, and Homer1 in the prefrontal cortex and dorsal hippocampus of adult female mice with a history of early-life stress.
In addition, we evaluated the expression of stress-related genes: glucocorticoid and mineralocorticoid receptors (Nr3c1 and Nr3c2) and Nr1d1, which encodes a transcription factor (also known as REVERBα) modulating sociability and anxiety-related behavior.
C57Bl/6 mice were exposed to either maternal separation (MS, 3 h once a day) or handling (HD, 15 min once a day) on postnatal days 2 through 14.
In adulthood, the behavior of female mice was analyzed by some behavioral tests, and on the day after the testing of social behavior, we measured the gene expression.
We found increased Npas4 expression only in the prefrontal cortex and higher Nr1d1 expression in both the prefrontal cortex and dorsal hippocampus of adult female mice with a history of MS.
The expression of the studied genes did not change in HD female mice.
The expression of stress-related genes Nr3c1 and Nr3c2 was unaltered in both groups.
We propose that the upregulation of Npas4 and Nr1d1 in females with a history of early-life stress and the corresponding enhancement of social behavior may be regarded as an adaptation mechanism reversing possible aberrations caused by early-life stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ryabushkina, Yuliya A.& Reshetnikov, Vasiliy V.& Bondar, Natalya P.. 2020. Maternal Separation Early in Life Alters the Expression of Genes Npas4 and Nr1d1 in Adult Female Mice: Correlation with Social Behavior. Behavioural Neurology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138415
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ryabushkina, Yuliya A.…[et al.]. Maternal Separation Early in Life Alters the Expression of Genes Npas4 and Nr1d1 in Adult Female Mice: Correlation with Social Behavior. Behavioural Neurology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1138415
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ryabushkina, Yuliya A.& Reshetnikov, Vasiliy V.& Bondar, Natalya P.. Maternal Separation Early in Life Alters the Expression of Genes Npas4 and Nr1d1 in Adult Female Mice: Correlation with Social Behavior. Behavioural Neurology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138415
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138415
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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