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Biochemical Constituents of Phaleria macrocarpa (Leaf) Methanolic Extract Inhibit ROS Production in SH-SY5Y Cells Model
المؤلفون المشاركون
Hassan, Ibrahim Maina
Wan Ibrahim, Wan Norhamidah
Binti Mohamat Yusuf, Ferdaus
Ahmad, Syahida
Ahmad, Siti Aqlima
المصدر
Biochemistry Research International
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Reactive oxygen species generation in mammalian cells profoundly affects several critical cellular functions, and the lack of efficient cellular detoxification mechanisms which remove these radicals may lead to several human diseases.
Several studies show that ROS is incriminated as destructive agents in the context of the nervous system especially with advance in age leading to neurodegeneration.
Current treatments of this disease are not effective and result in several side effects.
Thus, the search for alternative medicines is in high demand.
Therefore, the aim of this study is to evaluate the reactive oxygen inhibitory effect of Phaleria macrocarpa 80% (leaf) extract.
Methods.
The leaf was extracted with 80% methanol.
Cytotoxicity studies were carried out using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), and ROS inhibitory activities were evaluated using dichlorofluorescein diacetate (DCF-DA) assay in the SH-SY5Y cells model.
Results.
The result revealed ROS inhibitory activities of the crude extract with highly significant differences at p<0.001between the group that were treated with crude extract only, the group treated with crude extract and exposed to H2O2, and the group exposed to H2O2 only as well as the group that were maintained in complete media.
Bioactive compounds show the presence of vitexin and isovitexin following the HPLC method.
Conclusion.
High antioxidant activities and low toxicity effect of this crude revealed its high benefit to be used as natural medicine/supplements.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hassan, Ibrahim Maina& Wan Ibrahim, Wan Norhamidah& Binti Mohamat Yusuf, Ferdaus& Ahmad, Siti Aqlima& Ahmad, Syahida. 2020. Biochemical Constituents of Phaleria macrocarpa (Leaf) Methanolic Extract Inhibit ROS Production in SH-SY5Y Cells Model. Biochemistry Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1138443
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hassan, Ibrahim Maina…[et al.]. Biochemical Constituents of Phaleria macrocarpa (Leaf) Methanolic Extract Inhibit ROS Production in SH-SY5Y Cells Model. Biochemistry Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1138443
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hassan, Ibrahim Maina& Wan Ibrahim, Wan Norhamidah& Binti Mohamat Yusuf, Ferdaus& Ahmad, Siti Aqlima& Ahmad, Syahida. Biochemical Constituents of Phaleria macrocarpa (Leaf) Methanolic Extract Inhibit ROS Production in SH-SY5Y Cells Model. Biochemistry Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1138443
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138443
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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