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The Safety and Efficiency of Tirofiban in Acute Ischemic Stroke Patients Treated with Mechanical Thrombectomy: A Multicenter Retrospective Cohort Study
المؤلفون المشاركون
Zhao, Lili
Jian, Yating
Li, Tao
Wang, Heying
Lei, Zhang
Sun, Man
Li, Ye
Zhang, Yiheng
Dang, Meijuan
Huqing, Wang
Hong, Sun
Ru, Zhang
Zhang, Hongxing
Jia, Yi
Guogang, Luo
Guilian, Zhang
المصدر
Biochemistry Research International
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
Limited comparative studies have reported the safety and efficacy of tirofiban in acute ischemic stroke (AIS) patients after mechanical thrombectomy (MT).
Additionally, the available studies are inconsistent with each other, which makes application of tirofiban unclear in neuro-intervention.
Here, we performed a comparative retrospective study to investigate whether tirofiban combined with MT improves short- and long-term prognosis in AIS patients and whether its use is associated with complications.
Method.
Retrospective data were collected for AIS patients admitted between January 2013 and January 2019 at three stroke centers.
According to whether tirofiban was used during the operation, patients were divided into tirofiban group and control group.
Multivariate and COX regression analyses were performed to determine the association of tirofiban treatment with safety and efficiency in subjects treated with MT.
Result.
A total of 174 patients were analyzed, of whom 89 (51.1%) were treated with tirofiban.
There were no differences in the incidence of symptomatic intracerebral hemorrhage (10.2% vs.
10.6%, p=0.918), parenchymal hemorrhage type 2 (18.0% vs.
16.5%, p=0.793), and reocclusion at 24 h (3.4% vs.
10.6%, p=0.060) between the tirofiban group and control group.
Multivariate regression showed that tirofiban was not associated with intracerebral hemorrhage, early neurological deterioration, neurological improvement at 7 days, functional independence at 3-month and 9-month follow-up, or death at 9-month follow-up (adjusted p>0.05 for all).
However, AIS patients treated with MT + tirofiban showed a trend towards acquiring faster functional independence, with a median time to acquire functional independence of 4.0 months compared with 6.5 months in the control group (risk ratio = 1.49, 95% confidence interval 0.98–2.27; long rank p=0.066).
Conclusion.
Tirofiban may help AIS patients given MT to gain functional independence faster, without increasing the risk of complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Lili& Jian, Yating& Li, Tao& Wang, Heying& Lei, Zhang& Sun, Man…[et al.]. 2020. The Safety and Efficiency of Tirofiban in Acute Ischemic Stroke Patients Treated with Mechanical Thrombectomy: A Multicenter Retrospective Cohort Study. Biochemistry Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1138455
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Lili…[et al.]. The Safety and Efficiency of Tirofiban in Acute Ischemic Stroke Patients Treated with Mechanical Thrombectomy: A Multicenter Retrospective Cohort Study. Biochemistry Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1138455
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Lili& Jian, Yating& Li, Tao& Wang, Heying& Lei, Zhang& Sun, Man…[et al.]. The Safety and Efficiency of Tirofiban in Acute Ischemic Stroke Patients Treated with Mechanical Thrombectomy: A Multicenter Retrospective Cohort Study. Biochemistry Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1138455
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138455
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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