Flavonoid-Rich Extract of Dissotis rotundifolia Whole Plant Protects against Ethanol-Induced Gastric Mucosal Damage
المؤلفون المشاركون
Ansah, Charles
Martey, O. N. K.
Adinortey, Michael Buenor
Sarfo, Justice Kwabena
Nyarko, Alexander Kwadwo
Aboagye, Benjamin
المصدر
Biochemistry Research International
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Dissotis rotundifolia is a plant in the family Melastomataceae.
The methanolic extract of the whole plant is reported to be rich in C-glycosylflavones such as vitexin and orientin.
Though there are several reports on the ethnomedicinal use of this plant extract in stomach ulcers, experimental-based data is unavailable.
The drive for carrying out this research was to obtain data on the possible ameliorative effect of the whole plant extract of Dissotis rotundifolia (DRE) in gastric ulcerations induced by ethanol in Sprague Dawley (SD) rats.
SD rats were pretreated with 100, 300, and 500 mg/kg of DRE for 14 days after which an ulcerogen-ethanol was administered.
Gross examinations of the stomach lining and histological analysis of gastric lesions were carried out coupled with an assessment of the antioxidant activity of gastric mucosa using MDA, GSH, CAT, and SOD as indicators.
The data suggested a significant attenuation in gastric mucosal damage in DRE-pretreated ethanol-induced gastric ulcer reflected in the antioxidant status.
There was also a reduction or absence of hemorrhage, edema, and leucocytes infiltration in DRE-treated groups compared to the negative control group.
DRE conserved glutathione (GSH) levels, reduced malondialdehyde (MDA) levels, and enhanced catalase (CAT) and superoxide dismutase (SOD) enzyme levels.
The present study shows that DRE possess protective effects against ethanol-induced ulcer damage in the stomach of rats, which could be attributed to its antioxidant activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Adinortey, Michael Buenor& Ansah, Charles& Aboagye, Benjamin& Sarfo, Justice Kwabena& Martey, O. N. K.& Nyarko, Alexander Kwadwo. 2020. Flavonoid-Rich Extract of Dissotis rotundifolia Whole Plant Protects against Ethanol-Induced Gastric Mucosal Damage. Biochemistry Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138465
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Adinortey, Michael Buenor…[et al.]. Flavonoid-Rich Extract of Dissotis rotundifolia Whole Plant Protects against Ethanol-Induced Gastric Mucosal Damage. Biochemistry Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1138465
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Adinortey, Michael Buenor& Ansah, Charles& Aboagye, Benjamin& Sarfo, Justice Kwabena& Martey, O. N. K.& Nyarko, Alexander Kwadwo. Flavonoid-Rich Extract of Dissotis rotundifolia Whole Plant Protects against Ethanol-Induced Gastric Mucosal Damage. Biochemistry Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138465
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138465
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر