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Abnormal Biomarkers of Homocysteine Metabolism in Neonates with Conotruncal Heart Defects
المؤلفون المشاركون
Surmiak, Piotr
Baumert, Małgorzata
Paprotny, Magdalena
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-27
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objectives.
The etiology of conotruncal heart defects (CHD) remains unknown; however relation between homocysteine, folate levels, and congenital heart disease was found.
With this perspective in mind, the aim of the study was to investigate biomarkers of homosyteine metabolism pathway in mothers and their neonates with CHD.
Material and Methods.
Forty-three pairs of mothers and their neonates with CHD and forty pairs of mothers and neonates with nonconotruncal heart defects (non-CHD) were enrolled.
The control group (CG) consisted of fifty-nine pairs of mothers and their healthy neonates.
For estimating the plasma total homocysteine (tHcy), serum folates, and cobalamin levels, mothers’ venous blood samples and umbilical cord blood were taken in all groups.
Results.
We observed higher tHcy levels in newborns with CHD in comparison to their mothers and to neonates with non-CHD.
Cobalamin levels were significantly lower in neonates with CHD compared to other children.
Folates and cobalamin levels were lower in CHD mothers compared to their children.
Conclusions.
Elevated homocysteine levels in neonates with CHD and folate metabolism disturbances in their mothers were noticed.
The observed differences in homocysteine and cobalamin levels between neonates with CHD suggest the influence of various agents disturbing homocysteine metabolic pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Surmiak, Piotr& Baumert, Małgorzata& Paprotny, Magdalena. 2017. Abnormal Biomarkers of Homocysteine Metabolism in Neonates with Conotruncal Heart Defects. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1138559
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Surmiak, Piotr…[et al.]. Abnormal Biomarkers of Homocysteine Metabolism in Neonates with Conotruncal Heart Defects. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1138559
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Surmiak, Piotr& Baumert, Małgorzata& Paprotny, Magdalena. Abnormal Biomarkers of Homocysteine Metabolism in Neonates with Conotruncal Heart Defects. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1138559
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138559
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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