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Bredemolic Acid Improves Cardiovascular Function and Attenuates Endothelial Dysfunction in Diet-Induced Prediabetes: Effects on Selected Markers
المؤلفون المشاركون
Akinnuga, Akinjide Moses
Siboto, Angezwa
Khumalo, Bongiwe
Sibiya, Ntethelelo Hopewell
Ngubane, Phikelelani
Khathi, Andile
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Prediabetes is an intermediate hyperglycaemic state which has been associated with cardiovascular dysfunction.
However, cardiovascular dysfunction is not only caused by intermediate hyperglycaemia but also endothelial dysfunction, inflammation, and oxidative stress associated with prediabetes.
Bredemolic acid (BA), an isomer of maslinic acid, has been reported to ameliorate the intermediate hyperglycaemia found in prediabetes; however, the effects of this triterpene on cardiovascular function have not yet been determined.
Therefore, this study investigated the effects of BA on cardiovascular function in diet-induced prediabetic rats.
Thirty-six male rats that weighed 150–180 g were divided into two groups, the non-prediabetic (n = 6) and the prediabetic groups (n = 30), which were fed normal diet (ND) and HFHC diet, respectively.
The prediabetic rats were further subdivided into five groups (n = 6) and treated with either BA (80 mg/kg) or metformin (MET, 500 mg/kg) every third day for 12 weeks.
After 12 weeks, blood samples and the heart were collected for biochemical analysis.
The untreated prediabetic rats showed a significant increase in body mass index (BMI), waist circumference (WC), blood pressure, heart rate, lipid profile, lipid peroxidation, and inflammatory markers with significant decrease in endothelial function and antioxidant biomarkers by comparison with the non-prediabetic animals.
The administration of BA significantly improved cardiovascular functions such as blood pressure, heart rate, and endothelial function.
There was also a significant decrease in BMI, WC, lipid profile, lipid peroxidation, and inflammation with a concomitant increase in antioxidant capacity.
BA administration improved cardiovascular function by attenuation of oxidative stress, inflammatory, and endothelial dysfunction markers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Akinnuga, Akinjide Moses& Siboto, Angezwa& Khumalo, Bongiwe& Sibiya, Ntethelelo Hopewell& Ngubane, Phikelelani& Khathi, Andile. 2020. Bredemolic Acid Improves Cardiovascular Function and Attenuates Endothelial Dysfunction in Diet-Induced Prediabetes: Effects on Selected Markers. Cardiovascular Therapeutics،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138577
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Akinnuga, Akinjide Moses…[et al.]. Bredemolic Acid Improves Cardiovascular Function and Attenuates Endothelial Dysfunction in Diet-Induced Prediabetes: Effects on Selected Markers. Cardiovascular Therapeutics No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1138577
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Akinnuga, Akinjide Moses& Siboto, Angezwa& Khumalo, Bongiwe& Sibiya, Ntethelelo Hopewell& Ngubane, Phikelelani& Khathi, Andile. Bredemolic Acid Improves Cardiovascular Function and Attenuates Endothelial Dysfunction in Diet-Induced Prediabetes: Effects on Selected Markers. Cardiovascular Therapeutics. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138577
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138577
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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