Association of β-Blocker Therapy at Discharge with Clinical Outcomes after Acute Coronary Syndrome in Patients without Heart Failure
المؤلفون المشاركون
Xu, Bo
Chen, Yan
Tang, Xiao-fang
Gao, Run-lin
Yang, Yue-jin
Yuan, Jin-qing
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aim.
To evaluate the clinical impact of β-blocker in patients with adequate left ventricular ejection function (LVEF) who underwent percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS).
Methods.
A total of 10,724 consecutive patients who underwent PCI throughout 2013 were prospectively enrolled in the study.
Among these, we analyzed 5,631 ACS patients who were discharged with LVEF≥40%.
Patients were then compared according to the β-blocker prescription at discharge.
Results.
During a 2-year follow-up, no significant association was observed of β-blocker use with all-cause mortality (with β-blockers 47/5,043 (0.9%) vs.
without β-blocker use 8/588 (1.4%); hazard ratio (HR) 0.762, 95% confidence interval 0.36 to 1.64; P=0.485), cardiac death, myocardial infarction (MI), or major adverse cardiovascular and cerebrovascular events.
Subgroup analysis demonstrated that the β-blocker use at discharge reduced the 2-year mortality in patients with unstable angina (UA) (HR 0.42, 95% CI 0.19 to 0.94, P=0.034).
Landmark analysis at 1 year showed that patients with UA who were discharged with β-blockers had lower mortality (HR 0.17, 95% CI 0.04-0.65, P=0.010) and cardiac death (HR 0.12, 95% CI 0.01-0.99, P=0.049) than those discharged without β-blockers.
However, the benefit was lost beyond 1 year.
No differences in outcomes were recorded in the AMI or overall population.
Conclusions.
We present that β-blocker significantly lowers the rate of all-cause death up to 1 year, in UA patients who have undergone PCI and have adequate LVEF.
Its role in patients with AMI also deserves further exploration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yan& Tang, Xiao-fang& Gao, Run-lin& Yang, Yue-jin& Xu, Bo& Yuan, Jin-qing. 2020. Association of β-Blocker Therapy at Discharge with Clinical Outcomes after Acute Coronary Syndrome in Patients without Heart Failure. Cardiovascular Therapeutics،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138603
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yan…[et al.]. Association of β-Blocker Therapy at Discharge with Clinical Outcomes after Acute Coronary Syndrome in Patients without Heart Failure. Cardiovascular Therapeutics No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1138603
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yan& Tang, Xiao-fang& Gao, Run-lin& Yang, Yue-jin& Xu, Bo& Yuan, Jin-qing. Association of β-Blocker Therapy at Discharge with Clinical Outcomes after Acute Coronary Syndrome in Patients without Heart Failure. Cardiovascular Therapeutics. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138603
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138603
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر